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Milrinone, 98+%
Potent cAMP-specific phosphodiesterase inhibitor | CAS: 78415-72-2 | C12H9N3O | 211.224 g/mol
$323.05 - $1075.07
Chemical Identifiers
| CAS | 78415-72-2 |
|---|---|
| Molecular Formula | C12H9N3O |
| Molecular Weight (g/mol) | 211.224 |
| MDL Number | MFCD00133539 |
| InChI Key | PZRHRDRVRGEVNW-UHFFFAOYSA-N |
| Synonym | milrinone, primacor, corotrope, corotrop, milrinona, milrinonum, milrinonum latin, milrinona spanish, milrila, unii-ju9yax04c7 |
| PubChem CID | 4197 |
| ChEBI | CHEBI:50693 |
| IUPAC Name | 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile |
| SMILES | CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2 |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ62659MA
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Thermo Scientific Chemicals
J62659MA |
10 mg |
Each for $323.05
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AAJ62659MF
|
Thermo Scientific Chemicals
J62659MF |
50 mg |
Each for $1,075.07
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Description
It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsIt is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.
Solubility
Soluble in DMSO. Insoluble in water.
Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
Chemical Identifiers
| 78415-72-2 | |
| 211.224 | |
| PZRHRDRVRGEVNW-UHFFFAOYSA-N | |
| 4197 | |
| 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile |
| C12H9N3O | |
| MFCD00133539 | |
| milrinone, primacor, corotrope, corotrop, milrinona, milrinonum, milrinonum latin, milrinona spanish, milrila, unii-ju9yax04c7 | |
| CHEBI:50693 | |
| CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2 |
Specifications
| 78415-72-2 | |
| White | |
| MFCD00133539 | |
| UN2811 | |
| milrinone, primacor, corotrope, corotrop, milrinona, milrinonum, milrinonum latin, milrinona spanish, milrila, unii-ju9yax04c7 | |
| PZRHRDRVRGEVNW-UHFFFAOYSA-N | |
| 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile | |
| 4197 | |
| 211.22 | |
| Powder |
| 264°C | |
| C12H9N3O | |
| 10 mg | |
| 14,6197 | |
| Soluble in DMSO; Insoluble in water. | |
| CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2 | |
| 211.224 | |
| CHEBI:50693 | |
| ≥98% | |
| Milrinone |
Safety and Handling
GHS H Statement
H300-H311-H331
Fatal if swallowed.
Toxic in contact with skin.
Toxic if inhaled.
P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P311-P312-P330-P361-P363-P501c
H301+H311+H331
DOTInformation : Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber : 278-903-6
RTECSNumber : DW1762000
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only