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  7. Methyl diethylphosphonoacetate, 97%

Methyl diethylphosphonoacetate, 97%

Catalog No. AAA1064414
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Catalog No. AAA1064414 Supplier Thermo Scientific Chemicals Supplier No. A1064414
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Description

CAS: 1067-74-9 | C7H15O5P | 210.166 g/mol

Methyl diethylphosphonoacetate is used as a reagent in the preparation of allylic fluorides compounds and in regioselective Diels-Alder reactions. It also serves as a reactant in the preparation of substituted thiophenes and furans, which finds application in type 2 diabetes treatment. Further, it acts as a precursor in the synthesis of pyridone alkaloids and immunosuppressive cyclopentanediol derivatives. In addition to this, it is utilized in the modification of botulinum neurotoxin serotype A protease inhibitors.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Methyl diethylphosphonoacetate is used as a reagent in the preparation of allylic fluorides compounds and in regioselective Diels-Alder reactions. It also serves as a reactant in the preparation of substituted thiophenes and furans, which finds application in type 2 diabetes treatment. Further, it acts as a precursor in the synthesis of pyridone alkaloids and immunosuppressive cyclopentanediol derivatives. In addition to this, it is utilized in the modification of botulinum neurotoxin serotype A protease inhibitors.

Solubility
Miscible with tetrahydrofuran.

Notes
Incompatible with strong oxidizing agents.

Chemical Identifiers

CAS 1067-74-9
Molecular Formula C7H15O5P
Molecular Weight (g/mol) 210.166
MDL Number MFCD00009081
InChI Key CTSAXXHOGZNKJR-UHFFFAOYSA-N
Synonym methyl diethylphosphonoacetate, methyl 2-diethoxyphosphoryl acetate, acetic acid, diethoxyphosphinyl-, methyl ester, diethylmethylphosphonoacetate, methyl diethoxyphosphoryl acetate, diethyl carbomethoxymethylphosphonate, methyl 2-diethoxycarbonyl acetate, methyldiethylphosphonoacetate, diethyl methylphosphonoacetate, ksc489e0f
PubChem CID 66113
IUPAC Name methyl 2-diethoxyphosphorylacetate
SMILES CCOP(=O)(CC(=O)OC)OCC

Specifications

Density 1.145
Boiling Point 126°C to 128°C (8 mmHg)
Flash Point >110°C (230°F)
Refractive Index 1.432
Quantity 25 g
Beilstein 1782397
Solubility Information Miscible with tetrahydrofuran.
Formula Weight 210.17
Percent Purity 97%
Chemical Name or Material Methyl diethylphosphonoacetate

Safety and Handling

Hazard Category H315-H319-H335
Hazard Statement GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber 213-938-2
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only