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Methotrexate Pharmaceutical Secondary Standard, MilliporeSigma™ Supelco™

Catalog No. 111017836
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Catalog No. 111017836 Supplier Merck Emd Millipore Supplier No. PHR13961G
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Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.Methotrexate is an antagonist of folic acid that inhibits dihydrofolate reductase (DHFR) enzyme, reversibly and results in impaired DNA synthesis and cellular replication. Methotrexate has been used in treatment of rheumatoid arthritis and also for maintenance therapy in childhood acute lymphocytic leukemia (ALL).

Specifications

CAS 59-05-2
Purity Grade Notes These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Physical Form Neat
Linear Formula C20H22N8O5
MDL Number MFCD00064370
Synonym Methotrexate; (+)-Amethopterin; 4-Amino-10-methylfolic acid; 4-Amino-N10-methylpteroyl-L-glutamic acid; Antifolan; MTX; Methylaminopterin
Type Certified Reference Material
Quantity 1 g
Formula Weight 454.44
Grade Certified Reference Material