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Indomethacin, 99+%

Catalog No. p-7042656
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Catalog No. Quantity
AAJ6325503 1 g
AAJ6325506 5 g
AAJ6325514 25 g
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Catalog No. AAJ6325503

Supplier: Thermo Scientific Chemicals J6325503

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Description

Indomethacin, CAS # 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID). | CAS: 53-86-1 | C19H16ClNO4 | 357.79 g/mol

Non-selective cyclooxygenase inhibitorIndomethacin acts as an antiinflammatory, antipyretic and analgesic. It serves as an inhibitor cyclooxygenase such as Cox-1 and Cox-2. In addition to this, it is used as a prescription medication in order to reduce fever, stiffness, swelling and pain.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release
  • Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics
  • Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation

Applications

  • Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions
  • Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin

Chemical Identifiers

CAS 53-86-1
Molecular Formula C19H16ClNO4
Molecular Weight (g/mol) 357.79
MDL Number MFCD00057095
InChI Key CGIGDMFJXJATDK-UHFFFAOYSA-N
Synonym indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
PubChem CID 3715
ChEBI CHEBI:49662
IUPAC Name 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

Specifications

Melting Point 158°C to 161°C
Color White
Quantity 1 g
UN Number UN2811
Beilstein 497341
Sensitivity Light sensitive
Merck Index 14,4968
Solubility Information Soluble in ethanol and dimethyl sulfoxide.
Formula Weight 357.8
Percent Purity ≥99%
Physical Form Powder
Chemical Name or Material Indomethacin
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Safety and Handling

Hazard Category H300-H317-H360FD
Hazard Statement GHS H Statement
H300-H341
Fatal if swallowed.
Suspected of causing genetic defects.
Precautionary Statement P201-P202-P261-P264b-P270-P272-P280g-P281-P301+P310-P302+P352-P308+P313-P330-P333+P313-P363-P501c
DOTInformation Hazard Class: 6.1; Packaging Group: II
EINECSNumber 200-186-5
RTECSNumber NL3500000
TSCA Yes
Recommended Storage Ambient temperatures

RUO – Research Use Only