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Invitrogen™ Human STIM2 Synthetic Peptide

Catalog No. PEP0489
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50 μg
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Catalog No. Quantity
PEP0489 50 μg
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Catalog No. PEP0489 Supplier Invitrogen™ Supplier No. PEP0489

Description

Synthetic Peptide

This peptide corresponds to 18 amino acids near the carboxy terminus of human STIM2. PEP-0489 can be used as a blocking peptide with polyclonal antibody PA5-20372.

In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist.

Specifications

Species Human
Purification Method purified
Accession Number Q9P246
Common Name STIM2
Concentration 200 μg/mL
Format Liquid
Formulation PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
Gene Alias Kiaa1482; OTTHUMP00000123457; OTTHUMP00000123458; OTTHUMP00000216198; Stim2; Stromal interaction molecule 2
Gene Symbol STIM2
Lyophilized No
Preservative Sodium azide
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO
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