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Invitrogen™ Human RhoV (aa 195-236) Control Fragment Recombinant Protein

Catalog No. RP104211
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RP104211 100 μL
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Catalog No. RP104211 Supplier Invitrogen™ Supplier No. RP104211
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Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62781 (PA5-62781. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. Rho V (ras homolog gene family, member V), also known as Rho GTPase-like protein ARHV, CHP or WRCH2 (Wnt-1 responsive Cdc42 homolog 2), is a 236 amino acid protein that controls the actin cytoskeleton through activation of the JNK pathway. A member of the Rho family and small GTPase superfamily, Rho V functions as a lipid anchor at the cytoplasmic side of the cell membrane and is expressed in placenta, pancreas and fetal brain. Rho V is implicated in cell transformation and is encoded by a gene located on human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.

Specifications

Accession Number Q96L33
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 171177
Name Human RhoV (aa 195-236) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias A030005A06Rik; ARHV; calcium binding protein p22; CDC42-like GTPase 2; CHP; GTP-binding protein-like 2; ras homolog family member V; ras homolog gene family, member V; RGD:628824}; rho family GTPase Chp; Rho GTPase-like protein ARHV; rho-related GTP-binding protein RhoV; RHOV; rhov {ECO:0000312; Wnt-1 regulated Cdc42 homolog 2; Wnt-1 responsive Cdc42 homolog 2; WRCH1-related GTPase; WRCH2; WRCH-2
Common Name RhoV
Gene Symbol Rhov
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence KEVFDSAILSAIEHKARLEKKLNAKGVRTLSRCRWKKFFCFV
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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