missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Biochemical Reagents
  4. Peptides
  5. PEP175

Invitrogen™ Human 20S Proteasome Z (aa 263-277) Synthetic Peptide

Catalog No. PEP175
Change view
Click to view available options
Quantity:
50 μg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PEP175 50 μg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PEP175 Supplier Invitrogen™ Supplier No. PEP175

Description

Synthetic Peptide

PEP-175 is a 15 amino acid synthetic peptide whose sequence is from human proteasome 20S Z. The sequence of this peptide is (amino to carboxy terminus): C-E (263)-I-E-V-L-E-E-T-V-Q-T-M-D-T-S (NH2) (277) This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human proteasome 20S Z, catalog # PA1-979. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody. Reconstitute with 0.1 mL of distilled water.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).

Specifications

Gene ID (Entrez) 5695
Species Human
Purification Method purified
Accession Number Q99436
Common Name PSMB7
Concentration 0.5 mg/mL
Content And Storage -20°C. Avoid freeze-thaw cycles.
Description Synthetic Peptide
Format Lyophilized
Formulation Peptide with no preservative
For Use With (Application) Control
Gene Alias AU020723; beta-type proteasome 7 subunit; EGK_07890; hypothetical protein LOC511207; macropain chain Z; MC14; Mmc14; Multicatalytic endopeptidase complex chain Z; proteasome (prosome, macropain) subunit, beta type 7; proteasome (prosome, macropain) subunit, beta type, 7; proteasome 20S subunit beta 7; proteasome beta 7 subunit; proteasome catalytic subunit 2; proteasome subunit alpha; proteasome subunit beta 7; proteasome subunit beta type-7; proteasome subunit beta type-7 proprotein; proteasome subunit Z; protein serine kinase c17; Psmb7; RP11-101K10.7; Z
Gene Symbol Psmb7
Lyophilized Yes
Preservative No preservative
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO
Sequence C-E(263)-I-E-V-L-E-E-T-V-Q-T-M-D-T-S(NH2)(277)
Show More Show Less