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Thermo Scientific Chemicals Guanidine thiocyanate, Molecular Biology Grade

Catalog No. p-7043020
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AAJ6510418 50 g
AAJ6510430 250 g
AAJ6510436 500 g
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Catalog No. AAJ6510418 Supplier Thermo Scientific Chemicals Supplier No. J6510418
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Description

A protein denaturant | CAS: 593-84-0 | CH5N3·CHNS

Guanidine thiocyanate is used for RNA isolation and can solubilize proteins. When the compound is used to solubilize proteins it can be removed by dialysis against urea without difficulty. The hybridization of guanidine thiocyanate-solubilize hepatocytes can be used as a method to quantify mRNA from hepatocytes. Blood sample lysate stored in guanidine thiocyanate has been shown to maintain nucleic acid integrity. Research describes guanidine thiocyanate to be ineffective for RNA isolation of plant tissue with a high levels of secondary metabolites and storage proteins.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Guanidine thiocyanate is used for RNA isolation and can solubilize proteins. When the compound is used to solubilize proteins it can be removed by dialysis against urea without difficulty. The hybridization of guanidine thiocyanate-solubilize hepatocytes can be used as a method to quantify mRNA from hepatocytes. Blood sample lysate stored in guanidine thiocyanate has been shown to maintain nucleic acid integrity. Research describes guanidine thiocyanate to be ineffective for RNA isolation of plant tissue with a high levels of secondary metabolites and storage proteins.

Solubility
Soluble in water (1420 g/L) at 20°C, and ethanol (5%).

Notes
Light Sensitive. Keep container tightly closed. Store away from oxidizing agents.

Chemical Identifiers

CAS 593-84-0
Molecular Formula CH5N3·CHNS
MDL Number MFCD00013027
Synonym Guanidine rhodanide

Specifications

Melting Point 118°C to 122°C
Color White
Density 1.29
Quantity 50 g
Beilstein 3563461
Sensitivity Light sensitive
Solubility Information Soluble in water (1420g/L) at 20°C,and ethanol (5%).
Formula Weight 118.16
Grade Molecular Biology
Physical Form Powder
Chemical Name or Material Guanidine thiocyanate
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Safety and Handling

Hazard Category Skin corrosion/irritation (category 1), Hazardous to the aquatic environment (chronic category 3), Acute toxicity (category 4)
Hazard Statement Corrosive to the respiratory tract, Causes severe skin burns and eye damage, Contact with acids liberates very toxic gas, Harmful to aquatic life with long lasting effects, Harmful if swallowed, in contact with skin or if inhaled
DOTInformation Hazard Class: 8; Packaging Group: III
EINECSNumber 209-812-1
RTECSNumber XL1225000
TSCA Yes
Recommended Storage Ambient temperatures

RUO – Research Use Only