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Ethyl isocyanoacetate, 98%
Description
Ethyl isocyanoacetate is used in the syntheses of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles and oxazoles. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. It is a precursor used in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Ethyl isocyanoacetate is used in the syntheses of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles and oxazoles. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. It is a precursor used in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate.
Solubility
Miscible with organic solvents. Slightly miscible with water.
Notes
Store in cool place. Moisture and light sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents and strong bases.
Ethyl isocyanoacetate is used in the syntheses of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles and oxazoles. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. It is a precursor used in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate.
Solubility
Miscible with organic solvents. Slightly miscible with water.
Notes
Store in cool place. Moisture and light sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents and strong bases.
Specifications
Specifications
| Density | 1.035 |
| Boiling Point | 194°C to 196°C |
| Flash Point | 84°C (183°F) |
| Refractive Index | 1.422 |
| Quantity | 1 g |
| UN Number | UN2810 |
| Beilstein | 3588613 |
| Sensitivity | Light and moisture sensitive |
| Solubility Information | Miscible with organic solvents. Slightly miscible with water. |
| Formula Weight | 113.12 |
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Safety and Handling
| Hazard Category | H227-H302+H312+H332-H315-H319-H335 |
| Hazard Statement | GHS H Statement H331-H227-H302-H312-H315-H319-H335 Toxic if inhaled. Combustible liquid. Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. |
| Precautionary Statement | P210-P235-P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P370+P378q-P501c |
| DOTInformation | Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC, LIQUIDS, ORGANIC, N.O.S. |
| EINECSNumber | 221-077-9 |
| TSCA | No |
| Recommended Storage | Keep cold |
RUO – Research Use Only