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  8. (-)-Epigallocatechin Gallate, MP Biomedicals™

(-)-Epigallocatechin Gallate, MP Biomedicals™

Catalog No. MP219916550
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MP219916550 50 mg
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Catalog No. MP219916550 Supplier MP Biomedicals Inc Supplier No. 0219916550
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Description

Inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate, MP Biomedicals is a polyphenolic, tumor-inhibiting constituent of green tea. ECGC is an antioxidant polyphenol flavonoid that inhibits cellular oxidation of low density lipoprote

A natural component of green tea with a variety of biological functions:

  • Bocks the activation of EGF receptors and HER-2 receptors
  • Inhibits fatty acid synthase and glutamate dehydrogenase activity
  • Inhibits the peroxynitrite-induced formation of the oxidative injury markers 8-hydroxy-2-deoxy guanosine and 3-nitrotyrosine, apoptosis in human prostate cancer cells
  • Selectively inhibits activation of JNK/SAPK signaling pathway and suppresses proliferation of vascular smooth muscle cells
  • Shows growth inhibitory effects on tumor cells but not their normal counterparts
  • Inhibits telomerase, a fast-binding and reversible fatty acid synthase inhibitor
  • Inhibits PMA-induced skin thickening
  • Inhibits activation of interleukin-1a mRNA and protein expression
  • Inhibits nitric oxide synthase (iNOS) gene expression
  • At μM concentrations, inhibits VEGF-induced tyrosine phosphorylation

Chemical Identifiers

CAS 989-51-5
Molecular Formula C22H18O11
Molecular Weight (g/mol) 458.375
InChI Key WMBWREPUVVBILR-WIYYLYMNSA-N
Synonym =--epigallocatechin gallate, egcg, epigallocatechin gallate, epigallocatechin 3-gallate, tea catechin, epigallocatechin-3-gallate, =--epigallocatechin-3-o-gallate, teavigo, =--epigallocatechol gallate, epigallocatechin-3-monogallate
PubChem CID 65064
ChEBI CHEBI:4806
IUPAC Name [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
SMILES C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

Specifications

Melting Point 218°C (literature)
Quantity 50 mg
Solubility Information Soluble in water (5mg/mL, clear, faint pink colored solution).
Optical Rotation −185° ± 2° (ethanol) (Lit.)
Formula Weight 458.4g/mol
Percent Purity ≥95%
Physical Form Powder

Safety and Handling

Recommended Storage Store at 4°C.