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Doxepin hydrochloride

Catalog No. p-7042453
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Quantity:
1 g
25 g
5 g
Catalog No. Quantity
AAJ6257903 1 g
AAJ6257906 5 g
AAJ6257914 25 g
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Catalog No. AAJ6257903

Supplier: Thermo Scientific Chemicals J6257903

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Description

Potent H1-histamine receptor antagonist and a 5-HT receptor antagonist | CAS: 1229-29-4 | C19H22ClNO | 315.841 g/mol

It is a highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range. Also binds to the H4 histamine receptor (pKi = 6.79). Used clinically to treat anxiety and depression.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in water (100 mM), chloroform (1:2), alcohol (1:1), methanol, and DMSO.

Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Chemical Identifiers

CAS 1229-29-4
Molecular Formula C19H22ClNO
Molecular Weight (g/mol) 315.841
MDL Number MFCD00079135
InChI Key MHNSPTUQQIYJOT-SJDTYFKWSA-N
Synonym doxepin hydrochloride, novoxapin, aponal, toruan, curatin, sinequan, zonalon, adapin, doxepine hydrochloride, novoxapin hydrochloride
PubChem CID 6419921
IUPAC Name (3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride
SMILES CN(C)CCC=C1C2=CC=CC=C2COC3=CC=CC=C31.Cl

Specifications

Melting Point 187°C to 189°C
Color White
Quantity 1 g
UN Number UN2811
Merck Index 14,3435
Solubility Information Soluble in water (100 mM),chloroform (1:2),alcohol (1:1),methanol,and DMSO.
Formula Weight 315.84
Physical Form Powder
Chemical Name or Material Doxepin hydrochloride

Safety and Handling

Hazard Category H301-H361
Hazard Statement GHS H Statement
H301-H361
Toxic if swallowed.
Suspected of damaging fertility or the unborn child.
Precautionary Statement P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c
DOTInformation Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber 214-966-8
RTECSNumber HQ4375000
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only