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Docetaxel, 99%
Docetaxel, CAS # 114977-28-5, is a cytotoxic, semisynthetic, second-generation taxane derived from the needles of the European yew tree and displays antineoplastic, antibiotic, and antimicrotubule activities. | CAS: 114977-28-5 | C43H53NO14 | 807.89 g/mol
$342.97 - $1,671.32
Identifiants chimiques
| CAS | 114977-28-5 |
|---|---|
| Molecular Formula | C43H53NO14 |
| Molecular Weight (g/mol) | 807.89 |
| MDL Number | MFCD00800737 |
| InChI Key | ZDZOTLJHXYCWBA-VCVYQWHSSA-N |
| Synonym | docetaxel, taxotere, docetaxel anhydrous, docetaxol, emdoc, docetaxel, trihydrate, docetaxel inn, taxotere tn, unii-699121phca, txl |
| PubChem CID | 148124 |
| ChEBI | CHEBI:4672 |
| SMILES | CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O |
| Numéro de catalogue | Numéro du manufacturier. | Quantity | Prix | Quantity & Availability | |||||
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| Numéro de catalogue | Numéro du manufacturier. | Quantity | Prix | Quantity & Availability | |||||
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AAJ60174MC
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N/A | 100 mg |
chaque for $342.97
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AAJ60174ME
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N/A | 500 mg |
chaque for $919.22
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Connectez-vous ou enregistrez-vous pour vérifier votre prix et la disponibilité.
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AAJ6017403
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N/A | 1 g |
chaque for $1,671.32
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Connectez-vous ou enregistrez-vous pour vérifier votre prix et la disponibilité.
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Description
Docetaxel is a second-generation cytotoxic antimicrotubule agent and is mostly used in the pharmaceutical industry.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Docetaxel is an analog of taxol, and is considered to be a cytotoxic, semisynthetic, second-generation taxane that exhibits antineoplastic, antibiotic, and antimicrotubule activities
• Docetaxel is capable of inhibiting cellular mitosis. This compound promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability inhibits the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. This results in the persistence of abnormal microtubule structures leading to cell-cycle arrest and cell death
Application
• Docetaxel can inhibit angiogenesis by acting on vascular endothelial growth factor (VEGF) associated with cancer cells
• This compound has been used to investigate the effect of lysosomal autophagic flux in gastric cancer cells
Identifiants chimiques
| 114977-28-5 | |
| 807.89 | |
| ZDZOTLJHXYCWBA-VCVYQWHSSA-N | |
| 148124 | |
| CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O |
| C43H53NO14 | |
| MFCD00800737 | |
| docetaxel, taxotere, docetaxel anhydrous, docetaxol, emdoc, docetaxel, trihydrate, docetaxel inn, taxotere tn, unii-699121phca, txl | |
| CHEBI:4672 |
Spécifications
| 114977-28-5 | |
| White | |
| MFCD00800737 | |
| docetaxel, taxotere, docetaxel anhydrous, docetaxol, emdoc, docetaxel, trihydrate, docetaxel inn, taxotere tn, unii-699121phca, txl | |
| ZDZOTLJHXYCWBA-VCVYQWHSSA-N | |
| 807.89 | |
| CHEBI:4672 | |
| 99% | |
| Docetaxel |
| 186°C to 192°C | |
| C43H53NO14 | |
| 14,3397 | |
| Soluble in dimethyl sulfoxide and ethanol; Insoluble in water. | |
| CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O | |
| 148124 | |
| 807.88 | |
| Powder |
Sécurité et manipulation
P201-P202-P261-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362-P501c
H315-H319-H335-H361fd
RTECSNumber : DA4172750
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only