missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Biochemical Reagents
  4. Lipids and Lipid Derivatives
  5. Prenol lipids
  6. Diterpenoids
  7. Docetaxel, 99%

Docetaxel, 99%

Numéro de catalogue. AAJ60174ME
Change view
Click to view available options
Quantity:
100 mg
500 mg
1 g
3 product options available for selection
Product selection table with 3 available options. Use arrow keys to navigate and Enter or Space to select.
Numéro de catalogue. Quantity
AAJ60174ME 500 mg
AAJ60174MC 100 mg
AAJ6017403 1 g
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 3 options available.
3 options
Numéro de catalogue. AAJ60174ME Fournisseur Thermo Scientific Chemicals Code fournisseur J60174ME
Il en reste null

Description

Docetaxel, CAS # 114977-28-5, is a cytotoxic, semisynthetic, second-generation taxane derived from the needles of the European yew tree and displays antineoplastic, antibiotic, and antimicrotubule activities. | CAS: 114977-28-5 | C43H53NO14 | 807.89 g/mol

Docetaxel is a second-generation cytotoxic antimicrotubule agent and is mostly used in the pharmaceutical industry.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Docetaxel is an analog of taxol, and is considered to be a cytotoxic, semisynthetic, second-generation taxane that exhibits antineoplastic, antibiotic, and antimicrotubule activities
• Docetaxel is capable of inhibiting cellular mitosis. This compound promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability inhibits the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. This results in the persistence of abnormal microtubule structures leading to cell-cycle arrest and cell death

Application

• Docetaxel can inhibit angiogenesis by acting on vascular endothelial growth factor (VEGF) associated with cancer cells
• This compound has been used to investigate the effect of lysosomal autophagic flux in gastric cancer cells

Identifiants chimiques

CAS 114977-28-5
Molecular Formula C43H53NO14
Molecular Weight (g/mol) 807.89
MDL Number MFCD00800737
InChI Key ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Synonym docetaxel, taxotere, docetaxel anhydrous, docetaxol, emdoc, docetaxel, trihydrate, docetaxel inn, taxotere tn, unii-699121phca, txl
PubChem CID 148124
ChEBI CHEBI:4672
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O

Spécifications

Melting Point 186°C to 192°C
Color White
Quantity 500 mg
Merck Index 14,3397
Solubility Information Soluble in dimethyl sulfoxide and ethanol; Insoluble in water.
Formula Weight 807.88
Percent Purity 99%
Physical Form Powder
Chemical Name or Material Docetaxel

Sécurité et manipulation

Hazard Category H315-H319-H335-H361fd
Precautionary Statement P201-P202-P261-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362-P501c
RTECSNumber DA4172750
TSCA No
Recommended Storage Store at -20°C

RUO – Research Use Only