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Diosgenin

Catalog No. AAJ6097606
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Quantity:
100 g
25 g
5 g
Catalog No. Quantity
AAJ6097606 5 g
AAJ6097614 25 g
AAJ6097622 100 g
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Catalog No. AAJ6097606

Supplier: Thermo Scientific Chemicals J6097606

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Description

CAS: 512-04-9 | C27H42O3 | 414.63 g/mol

Diosgenin is the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills. The unmodified steroid has estrogenic activity and can reduce the level of serum cholesterol. Diosgenin has been used in traditional medicine as an antihypercholesterolemia, antihypertriacylglycerolemia, antidiabetes and antihyperglycemia agent. Diosgenin is a steroid sapogenin used in the semi-synthesis of pregnenolone, cortisone, and progesterone. Diosgenin has estrogenic activity and can reduce the level of serum cholesterol.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Diosgenin is the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills. The unmodified steroid has estrogenic activity and can reduce the level of serum cholesterol. Diosgenin has been used in traditional medicine as an antihypercholesterolemia, antihypertriacylglycerolemia, antidiabetes and antihyperglycemia agent. Diosgenin is a steroid sapogenin used in the semi-synthesis of pregnenolone, cortisone, and progesterone. Diosgenin has estrogenic activity and can reduce the level of serum cholesterol.

Solubility
Soluble in chloroform (50 mg/ml), ethanol (83 mg/ml at 25°C), water (<1mg/mL at 25°C), DMSO (<1mg/mL at 25°C), and methanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Chemical Identifiers

CAS 512-04-9
Molecular Formula C27H42O3
Molecular Weight (g/mol) 414.63
MDL Number MFCD00016887,MFCD01002142
InChI Key WQLVFSAGQJTQCK-VKROHFNGSA-N
Synonym 3-beta-Hydroxy-5-spirostene; Nitogenin
PubChem CID 46783391
IUPAC Name (1'S,2R,2'S,4'S,5R,7'S,8'R,9'S,12'S,13'R,16'S)-5,7',9',13'-tetramethyl-5'-oxaspiro[oxane-2,6'-pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosan]-18'-en-16'-ol
SMILES C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)O[C@]11CC[C@@H](C)CO1

Specifications

Melting Point 200°C to 206°C
Color White
Quantity 5 g
Beilstein 94582
Merck Index 14,3295
Solubility Information Soluble in chloroform (50mg/ml),ethanol (83mg/ml at 25°C),water (<1mg/ml at 25°C),DMSO (<1mg/ml at 25°C),and methanol.
Formula Weight 414.63
Physical Form Powder
Chemical Name or Material Diosgenin

Safety and Handling

EINECSNumber 208-134-3
RTECSNumber WH1450000
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only