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Diethyl (bromodifluoromethyl)phosphonate, 97%

CAS: 65094-22-6 | C5H10BrF2O3P | 267.01 g/mol

$59.14 - $559.60

Chemical Identifiers

CAS 65094-22-6
Molecular Formula C5H10BrF2O3P
Molecular Weight (g/mol) 267.01
MDL Number MFCD00069118
InChI Key QRADKVYIJIAENZ-UHFFFAOYSA-N
Synonym diethyl bromodifluoromethyl phosphonate, bromodifluoromethyl diethylphosphonate, diethyl bromodifluoromethanephosphonate, diethyl bromodifluoromethylphosphonate, bromodifluoromethyl phosphonic acid diethyl ester, 1-bromo difluoro methyl-ethoxyphosphoryl oxyethane, phosphonic acid, bromodifluoromethyl-, diethyl ester, pubchem24183, acmc-20ai7p
PubChem CID 144101
IUPAC Name 1-[[bromo(difluoro)methyl]-ethoxyphosphoryl]oxyethane
SMILES CCOP(=O)(OCC)C(F)(F)Br
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AAL1671503
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Thermo Scientific Chemicals
L1671503
1 g
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AAL1671506
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Thermo Scientific Chemicals
L1671506
5 g
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AAL1671514
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Thermo Scientific Chemicals
L1671514
25 g
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Description

Description

Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.

Solubility
Not miscible or difficult to mix in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.
Specifications

Chemical Identifiers

65094-22-6
267.01
QRADKVYIJIAENZ-UHFFFAOYSA-N
144101
CCOP(=O)(OCC)C(F)(F)Br
C5H10BrF2O3P
MFCD00069118
diethyl bromodifluoromethyl phosphonate, bromodifluoromethyl diethylphosphonate, diethyl bromodifluoromethanephosphonate, diethyl bromodifluoromethylphosphonate, bromodifluoromethyl phosphonic acid diethyl ester, 1-bromo difluoro methyl-ethoxyphosphoryl oxyethane, phosphonic acid, bromodifluoromethyl-, diethyl ester, pubchem24183, acmc-20ai7p
1-[[bromo(difluoro)methyl]-ethoxyphosphoryl]oxyethane

Specifications

65094-22-6
99°C to 102°C (16 mmHg)
C5H10BrF2O3P
MFCD00069118
1944045
Not miscible or difficult to mix in water.
CCOP(=O)(OCC)C(F)(F)Br
267.01
267.01
Diethyl (bromodifluoromethyl)phosphonate
1.503
>110°C (230°F)
1.416
1 g
diethyl bromodifluoromethyl phosphonate, bromodifluoromethyl diethylphosphonate, diethyl bromodifluoromethanephosphonate, diethyl bromodifluoromethylphosphonate, bromodifluoromethyl phosphonic acid diethyl ester, 1-bromo difluoro methyl-ethoxyphosphoryl oxyethane, phosphonic acid, bromodifluoromethyl-, diethyl ester, pubchem24183, acmc-20ai7p
QRADKVYIJIAENZ-UHFFFAOYSA-N
1-[[bromo(difluoro)methyl]-ethoxyphosphoryl]oxyethane
144101
97%
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Safety and Handling

Safety and Handling

GHS H Statement
H315-H319
Causes skin irritation.
Causes serious eye irritation.

P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362

H315-H319

TSCA : No

Recommended Storage : Ambient temperatures

SDS
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RUO – Research Use Only