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  6. Di-tert-butyl N,N-diethylphosphoramidite, 94%

Di-tert-butyl N,N-diethylphosphoramidite, 94%

Catalog No. p-7029867
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Quantity:
5 g
Catalog No. Quantity
AAH2738006 5 g
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Catalog No. AAH2738006

Supplier: Thermo Scientific Chemicals H2738006

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Description

CAS: 117924-33-1 | C12H28NO2P | 249.335 g/mol

A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.

Solubility
Hydrolyzes in water. Soluble in chloroform and methanol.

Notes
Moisture sensitive. Store away from water/moisture, heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated. Keep ignition sources away.

Chemical Identifiers

CAS 117924-33-1
Molecular Formula C12H28NO2P
Molecular Weight (g/mol) 249.335
MDL Number MFCD00134307
InChI Key KUKSUQKELVOKBH-UHFFFAOYSA-N
Synonym di-tert-butyl n,n-diethylphosphoramidite, di-tert-butyl diethylphosphoramidite, di-t-butyl n,n-diethylphosphoramidite, phosphoramidous acid, diethyl-, bis 1,1-dimethylethyl ester, n-bis 2-methylpropan-2-yl oxy phosphanyl-n-ethylethanamine, acmc-1c42i, di-t-butyl diethylphosphoramidite, di-tert-butyl diethylamidophosphite, di-tert-butoxy diethylamino phosphine
PubChem CID 4251849
IUPAC Name N-[bis[(2-methylpropan-2-yl)oxy]phosphanyl]-N-ethylethanamine
SMILES CCN(CC)P(OC(C)(C)C)OC(C)(C)C

Specifications

Density 0.896
Boiling Point 39°C to 41°C (0.3 mmHg)
Flash Point 78°C (172°F)
Refractive Index 1.434
Quantity 5 g
Sensitivity Moisture sensitive; May form a precipitate
Solubility Information Hydrolyzes in water. Soluble in chloroform and methanol.
Formula Weight 249.33
Percent Purity 94%
Chemical Name or Material Di-tert-butyl N,N-diethylphosphoramidite

Safety and Handling

Hazard Category H227-H315-H319
Hazard Statement GHS H Statement
H315-H319-H227
Causes skin irritation.
Causes serious eye irritation.
Combustible liquid.
Precautionary Statement P210-P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362-P370+P378q-P501c
TSCA No
Recommended Storage Keep cold

RUO – Research Use Only