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Di-tert-butyl N,N-diethylphosphoramidite, 94%
CAS: 117924-33-1 | C12H28NO2P | 249.335 g/mol
Supplier: Thermo Scientific Chemicals H2738006
Description
A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsA useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.
Solubility
Hydrolyzes in water. Soluble in chloroform and methanol.
Notes
Moisture sensitive. Store away from water/moisture, heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated. Keep ignition sources away.
Specifications
| Di-tert-butyl N,N-diethylphosphoramidite | |
| 0.896 | |
| 78°C (172°F) | |
| 1.434 | |
| 5 g | |
| di-tert-butyl n,n-diethylphosphoramidite, di-tert-butyl diethylphosphoramidite, di-t-butyl n,n-diethylphosphoramidite, phosphoramidous acid, diethyl-, bis 1,1-dimethylethyl ester, n-bis 2-methylpropan-2-yl oxy phosphanyl-n-ethylethanamine, acmc-1c42i, di-t-butyl diethylphosphoramidite, di-tert-butyl diethylamidophosphite, di-tert-butoxy diethylamino phosphine | |
| KUKSUQKELVOKBH-UHFFFAOYSA-N | |
| N-[bis[(2-methylpropan-2-yl)oxy]phosphanyl]-N-ethylethanamine | |
| 4251849 | |
| 94% |
| 117924-33-1 | |
| 39°C to 41°C (0.3 mmHg) | |
| C12H28NO2P | |
| MFCD00134307 | |
| Moisture sensitive; May form a precipitate | |
| Hydrolyzes in water. Soluble in chloroform and methanol. | |
| CCN(CC)P(OC(C)(C)C)OC(C)(C)C | |
| 249.335 | |
| 249.33 |
Chemical Identifiers
| 117924-33-1 | |
| 249.335 | |
| KUKSUQKELVOKBH-UHFFFAOYSA-N | |
| 4251849 | |
| CCN(CC)P(OC(C)(C)C)OC(C)(C)C |
| C12H28NO2P | |
| MFCD00134307 | |
| di-tert-butyl n,n-diethylphosphoramidite, di-tert-butyl diethylphosphoramidite, di-t-butyl n,n-diethylphosphoramidite, phosphoramidous acid, diethyl-, bis 1,1-dimethylethyl ester, n-bis 2-methylpropan-2-yl oxy phosphanyl-n-ethylethanamine, acmc-1c42i, di-t-butyl diethylphosphoramidite, di-tert-butyl diethylamidophosphite, di-tert-butoxy diethylamino phosphine | |
| N-[bis[(2-methylpropan-2-yl)oxy]phosphanyl]-N-ethylethanamine |
Safety and Handling
GHS H Statement
H315-H319-H227
Causes skin irritation.
Causes serious eye irritation.
Combustible liquid.
P210-P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362-P370+P378q-P501c
H227-H315-H319
TSCA : No
Recommended Storage : Keep cold
RUO – Research Use Only