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  8. Dexamethasone 21-phosphate disodium salt, 98%

Dexamethasone 21-phosphate disodium salt, 98%

Catalog No. p-7042873
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Quantity:
1 g
5 g
Catalog No. Quantity
AAJ6408303 1 g
AAJ6408306 5 g
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Catalog No. AAJ6408303

Supplier: Thermo Scientific Chemicals J6408303

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Description

Dexamethasone 21-phosphate disodium salt, CAS # 2392-39-4, is a synthetic adrenal glucocorticoid with potent anti-inflammatory activity. | CAS: 2392-39-4 | C22H28FNa2O8P | 516.41 g/mol

Dexamethasone 21-phosphate disodium salt acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter. It is used in the treatment of emetic effects of cancer therapy and epicondylitis. Further, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Dexamethasone 21-phosphate disodium salt is a sodium phosphate salt form of dexamethasone, considered to be a synthetic adrenal glucocorticoid with anti-inflammatory activity

Application

  • Dexamethasone 21-phosphate disodium salt binds to specific nuclear steroid receptors, interfering with NF-kB activation and apoptotic pathways
  • It acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter
  • It has been used as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 in the induced reactivation and spontaneous shedding rabbit models
  • This compound is used to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs

Chemical Identifiers

CAS 2392-39-4
Molecular Formula C22H28FNa2O8P
Molecular Weight (g/mol) 516.41
MDL Number MFCD00079105
InChI Key PLCQGRYPOISRTQ-FCJDYXGNSA-L
Synonym dexamethasone sodium phosphate, dexamethasone 21-phosphate disodium salt, dalalone, dexadreson, dexagro, megacort, soldesam, spersadox, decdan, solu-decadron
PubChem CID 16961
ChEBI CHEBI:4462
IUPAC Name disodium;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

Specifications

Melting Point 233°C to 240°C
Color White
Quantity 1 g
Beilstein 6473066
Merck Index 142943
Solubility Information Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.
Formula Weight 516.4
Percent Purity 98%
Physical Form Powder
Chemical Name or Material Dexamethasone 21-phosphate disodium salt

Safety and Handling

Hazard Category Acute toxicity (category 4), Reproductive toxicity (category 2), Specific target organ toxicity after repeated exposure (category 2)
Hazard Statement Harmful if swallowed, Suspected of damaging the unborn child, May cause damage to organs through prolonged or repeated exposure
EINECSNumber 219-243-0
RTECSNumber TU4056000
TSCA Yes
Recommended Storage Keep cold

RUO – Research Use Only