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  6. Thermo Scientific Chemicals D-Mannosamine hydrochloride, 98%

Thermo Scientific Chemicals D-Mannosamine hydrochloride, 98%

Catalog No. AAJ66316ME
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AAJ6631603 1 g
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Catalog No. AAJ66316ME Supplier Thermo Scientific Chemicals Supplier No. J66316ME
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Description

CAS: 5505-63-5 | C6H14ClNO5 | 215.63 g/mol

D-Mannosamine hydrochloride is used in the synthesis of non-natural Mannac analogs for the expression of thiols on cell-surface sialic acids. It is also used to investigate and screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis. It acts as a precursor of N-propanoyl mannosamine and other N-acyl precursors of sialic acid (N-acyl neuraminic acids). It is a pharmaceutical compound used in the development of mannosylated liposomes for bioadhesive oral drug delivery through M cells of Peyer's patches.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
D-Mannosamine hydrochloride is used in the synthesis of non-natural Mannac analogs for the expression of thiols on cell-surface sialic acids. It is also used to investigate and screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis. It acts as a precursor of N-propanoyl mannosamine and other N-acyl precursors of sialic acid (N-acyl neuraminic acids). It is a pharmaceutical compound used in the development of mannosylated liposomes for bioadhesive oral drug delivery through M cells of Peyer′s patches.

Solubility
Soluble in water and methanol.

Notes
Hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents.

Chemical Identifiers

CAS 5505-63-5
Molecular Formula C6H14ClNO5
Molecular Weight (g/mol) 215.63
MDL Number MFCD00064557
InChI Key CBOJBBMQJBVCMW-DEZHIRTDSA-N
Synonym 2-amino-2-deoxy-d-mannosehydrochloride
PubChem CID 133109008
IUPAC Name (2R,3S,4R,5S)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride
SMILES C(C(C(C(C(C=O)N)O)O)O)O.Cl

Specifications

Melting Point 168°C (decomposition)
Color White
Quantity 500 mg
Sensitivity Hygroscopic
Solubility Information Soluble in water and methanol.
Optical Rotation −4° (c=2 in Water)
Formula Weight 215.63
Percent Purity 98%
Physical Form Powder
Chemical Name or Material D-Mannosamine hydrochloride

Safety and Handling

Hazard Category H302-H315-H317-H319-H335
Precautionary Statement P261-P264b-P270-P271-P272-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P310-P330-P333+P313-P362-P501c
EINECSNumber 226-847-8
TSCA Yes
Recommended Storage Keep cold; Store under Argon

RUO – Research Use Only