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Gibco™ CTS™ Dynabeads™ Treg Xpander

Numéro de catalogue. 46000D
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Numéro de catalogue. Quantity
46000D 1 Vial
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Numéro de catalogue. 46000D Fournisseur Gibco™ Code fournisseur 46000D

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Description

Optimized for the ex vivo activation and expansion of regulatory T cells (Tregs), CTS Dynabeads Treg Xpander provides more specific and higher fold expansion compared to our CTS Dynabeads CD3/CD28.

Optimized for the ex vivo activation and expansion of regulatory T cells (Tregs), CTS Dynabeads Treg Xpander provides more specific and higher fold expansion compared to our CTS Dynabeads CD3/CD28. Tregs activated and expanded with this product show suppressive activity and display the characteristic Treg cytokine profile and phenotype. Furthermore, high stability of the expanded Tregs has been demonstrated through analysis of the Treg-specific demethylated region.

CTS Dynabeads Treg Xpander features include:

  • Aseptically manufactured and ready for clinical trials and cell therapy manufacturing process development
  • Drug Master File (DMF) to cross-reference in IND applications
  • >800 fold expansion after two stimulations
  • Treg phenotype (FOXP3) and suppressive function maintained

Regulatory T cells (CD4+ CD25+ FOXP3+) are a suppressive subset of CD4+ T helper cells and are important for the regulation of immune responses. Due to a relative frequency of 1–2% of the total lymphocyte population, ex vivo expansion of Tregs prior to adoptive transfer is expected for most clinical applications.

Spécifications

Cell Type T Cells (Regulatory)
Content And Storage 10 mL CTS Dynabeads Treg Xpander, 2x108 beads/mL, store at 2–8°C
Product Type Treg Expander
Product Line Dynabeads
Quantity 1 Vial
Shipping Condition Wet Ice
Target Species Human

For Research Use or Manufacturing of Cell, Gene, or Tissue-Based Products. CAUTION: Not intended for direct administration into humans or animals.