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(-)-Cotinine, 98%
CAS: 486-56-6 | C10H12N2O | 176.219 g/mol
$148.29 - $368.95
Chemical Identifiers
| CAS | 486-56-6 |
|---|---|
| Molecular Formula | C10H12N2O |
| Molecular Weight (g/mol) | 176.219 |
| MDL Number | MFCD00077696 |
| InChI Key | UIKROCXWUNQSPJ-VIFPVBQESA-N |
| Synonym | cotinine, --cotinine, cotinina, cotininum, cotinine-, s-cotinine, s---cotinine, unii-k5161x06ll, s-1-methyl-5-3-pyridinyl-2-pyrrolidinone, 2-pyrrolidinone, 1-methyl-5-3-pyridinyl-, 5s |
| PubChem CID | 854019 |
| ChEBI | CHEBI:68641 |
| IUPAC Name | (5S)-1-methyl-5-pyridin-3-ylpyrrolidin-2-one |
| SMILES | CN1C(CCC1=O)C2=CN=CC=C2 |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAL11873MD
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Thermo Scientific Chemicals
L11873MD |
250 mg |
Each for $148.29
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AAL1187303
|
Thermo Scientific Chemicals
L1187303 |
1 g |
Each for $368.95
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Description
(-)-Cotinine is used to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
SolubilityNot miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature is 2 - 8°C.
Chemical Identifiers
| 486-56-6 | |
| 176.219 | |
| UIKROCXWUNQSPJ-VIFPVBQESA-N | |
| 854019 | |
| (5S)-1-methyl-5-pyridin-3-ylpyrrolidin-2-one |
| C10H12N2O | |
| MFCD00077696 | |
| cotinine, --cotinine, cotinina, cotininum, cotinine-, s-cotinine, s---cotinine, unii-k5161x06ll, s-1-methyl-5-3-pyridinyl-2-pyrrolidinone, 2-pyrrolidinone, 1-methyl-5-3-pyridinyl-, 5s | |
| CHEBI:68641 | |
| CN1C(CCC1=O)C2=CN=CC=C2 |
Specifications
| 486-56-6 | |
| 145°C to 147°C (3 mmHg) | |
| C10H12N2O | |
| 250 mg | |
| 14,2553 | |
| Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM),ethanol (50mg/ml,yielding a clear,faint yellow to yellow solution),methanol and chloroform. | |
| −20° (c=1 in Ethanol) | |
| (5S)-1-methyl-5-pyridin-3-ylpyrrolidin-2-one | |
| 854019 | |
| 176.22 | |
| (-)-Cotinine |
| 34°C to 39°C | |
| >110°C (230°F) | |
| MFCD00077696 | |
| 83099 | |
| cotinine, --cotinine, cotinina, cotininum, cotinine-, s-cotinine, s---cotinine, unii-k5161x06ll, s-1-methyl-5-3-pyridinyl-2-pyrrolidinone, 2-pyrrolidinone, 1-methyl-5-3-pyridinyl-, 5s | |
| UIKROCXWUNQSPJ-VIFPVBQESA-N | |
| CN1C(CCC1=O)C2=CN=CC=C2 | |
| 176.219 | |
| CHEBI:68641 | |
| 98% |
Safety and Handling
GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
H302-H315-H319-H335
EINECSNumber : 207-634-9
RTECSNumber : GN1925500
TSCA : No
Recommended Storage : Keep cold
RUO – Research Use Only