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  7. CGS 21680 hydrochloride, 99%

CGS 21680 hydrochloride, 99%

Catalog No. p-7041942
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AAJ60793LB0 5 mg
AAJ60793MA 10 mg
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Catalog No. AAJ60793LB0 Supplier Thermo Scientific Chemicals Supplier No. J60793LB0
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Description

An A2A Adenosine receptor agonist | CAS: 120225-54-9 | C23H30ClN7O6 | 535.986 g/mol

CGS 21680 hydrochloride is currently used in research in studying neuronal transmission, also in respiration. CGS 21680 is commonly used to study the actions of the adenosine A2A receptor in cells and tissues. CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor. CGS 21680C effectively increases coronary flow with an ED25 value of 1.8 nM. In hippocampal slices, CGS 21680 apis weak agonist on pre- and postsynaptic measures of electrophysiologicaJ activity.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
CGS 21680 hydrochloride is currently used in research in studying neuronal transmission, also in respiration. CGS 21680 is commonly used to study the actions of the adenosine A2A receptor in cells and tissues. CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor. CGS 21680C effectively increases coronary flow with an ED25 value of 1.8 nM. In hippocampal slices, CGS 21680 apis weak agonist on pre- and postsynaptic measures of electrophysiologicaJ activity.

Solubility
Soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Chemical Identifiers

CAS 120225-54-9
Molecular Formula C23H30ClN7O6
Molecular Weight (g/mol) 535.986
MDL Number MFCD11045878
InChI Key QPHVMNOEKKJYJO-XWOZMEDYSA-N
Synonym cgs-21680 hydrochloride hydrate, 3-4-2-6-amino-9-2r,3r,4s,5s-5-ethylcarbamoyl-3,4-dihydroxyoxolan-2-yl purin-2-yl amino ethyl phenyl propanoic acid hydrate hydrochloride, c23h29n7o6.clh.h2o, cgs-21680 hydrochloride hydrate, solid, 2-p-2-carboxyethyl phenethylamino-5 inverted exclamation marka-n-ethylcarboxamidoadenosine hydrochloride hydrate
PubChem CID 133639586
IUPAC Name 3-[4-[2-[[6-amino-9-[(2S,4S,5R)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid;hydrochloride
SMILES CCNC(=O)C1C(C(C(O1)N2C=NC3=C2N=C(N=C3N)NCCC4=CC=C(C=C4)CCC(=O)O)O)O.Cl

Specifications

Color White
Quantity 5 mg
Solubility Information Soluble up to 3.4mg/mL in DMSO and 20mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin.
Formula Weight 535.98
Percent Purity 99%
Physical Form Solid
Chemical Name or Material CGS 21680 hydrochloride

Safety and Handling

TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only