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Thermo Scientific Chemicals Calpain Inhibitor II, 95+%
An inhibitor of calpains I and II
$887.95 - $887.95
Chemical Identifiers
| CAS | 136632-32-1 |
|---|---|
| Molecular Formula | C19H35N3O4S |
| Synonym | N-Ac-Leu-Leu-Methioninal; ALLM |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ62491MB
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Thermo Scientific Chemicals
J62491MB |
25 mg |
Each for $887.95
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Description
ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and IIÂ in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Chemical Identifiers
| 136632-32-1 | |
| C19H35N3O4S | |
| N-Ac-Leu-Leu-Methioninal; ALLM |
Specifications
| 25 mg | |
| -30°C to -10°C | |
| 136632-32-1 | |
| 401.60g/mol | |
| Soluble in ethanol at 20mg/ml | |
| Powder | |
| RJWLAIMXRBDUMH-UHFFFAOYNA-N | |
| 2-acetamido-4-methyl-N-(3-methyl-1-{[4-(methylsulfanyl)-1-oxobutan-2-yl]carbamoyl}butyl)pentanamide | |
| ≥95% |
| White | |
| An inhibitor of calpains I and II | |
| C19H35N3O4S | |
| N-Ac-Leu-Leu-Methioninal; ALLM | |
| Signal Transduction Reagent | |
| 7693643 | |
| CSCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(C)=O)C=O | |
| 401.57 |
Safety and Handling
Recommended Storage : Store at -20°C
RUO – Research Use Only