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Bisindolylmaleimide 1, Thermo Scientific Chemicals
Very potent and selective inhibitor of protein kinase C
$310.70 - $849.11
Chemical Identifiers
| CAS | 133052-90-1 |
|---|---|
| Molecular Formula | C25H24N4O2 |
| Molecular Weight (g/mol) | 412.493 |
| MDL Number | MFCD00236428 |
| InChI Key | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
| Synonym | bisindolylmaleimide i, unii-l79h6n0v6c, rbt205 inhibitor, gö 6850, bisindolylmaleimide i gf 109203x, bim-1, chembl7463, 2-1-3-dimethylaminopropyl indol-3-yl-3-indol-3-yl maleimide, 3-1-3-dimethylamino propyl-1h-indol-3-yl-4-1h-indol-3-yl-1h-pyrrole-2,5-dione |
| PubChem CID | 2396 |
| ChEBI | CHEBI:41072 |
| IUPAC Name | 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione |
| SMILES | CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54 |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ63401LB0
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Thermo Scientific Chemicals
J63401LB0 |
5 mg |
Each for $310.70
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AAJ63401MB
|
Thermo Scientific Chemicals
J63401MB |
25 mg |
Each for $849.11
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Description
Bisindolylmaleimide is used as a highly selective inhibitor of all PKC isoforms and slight inhibitor of GSK-3, used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals, very potent and selective inhibitor of protein kinase C.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsBisindolylmaleimide is used as a highly selective inhibitor of all PKC isoforms and slight inhibitor of GSK-3, used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals, very potent and selective inhibitor of protein kinase C.
Solubility
Insoluble in water.
Notes
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
Chemical Identifiers
| 133052-90-1 | |
| 412.493 | |
| QMGUOJYZJKLOLH-UHFFFAOYSA-N | |
| 2396 | |
| 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione |
| C25H24N4O2 | |
| MFCD00236428 | |
| bisindolylmaleimide i, unii-l79h6n0v6c, rbt205 inhibitor, gö 6850, bisindolylmaleimide i gf 109203x, bim-1, chembl7463, 2-1-3-dimethylaminopropyl indol-3-yl-3-indol-3-yl maleimide, 3-1-3-dimethylamino propyl-1h-indol-3-yl-4-1h-indol-3-yl-1h-pyrrole-2,5-dione | |
| CHEBI:41072 | |
| CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54 |
Specifications
| 133052-90-1 | |
| C25H24N4O2 | |
| 5 mg | |
| Insoluble in water. | |
| CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54 | |
| 412.493 | |
| CHEBI:41072 | |
| Crystalline Powder |
| Orange | |
| MFCD00236428 | |
| bisindolylmaleimide i, unii-l79h6n0v6c, rbt205 inhibitor, gö 6850, bisindolylmaleimide i gf 109203x, bim-1, chembl7463, 2-1-3-dimethylaminopropyl indol-3-yl-3-indol-3-yl maleimide, 3-1-3-dimethylamino propyl-1h-indol-3-yl-4-1h-indol-3-yl-1h-pyrrole-2,5-dione | |
| QMGUOJYZJKLOLH-UHFFFAOYSA-N | |
| 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione | |
| 2396 | |
| 412.48 | |
| Bisindolylmaleimide 1 |
Safety and Handling
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only