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Bafilomycin A1
Bafilomycin A1, CAS # 88899-55-2, is an inhibitor of vacuolar ATPases from Streptomyces griseus that has antibacterial, antifungal, and antineoplastic activity. | CAS: 88899-55-2 | C35H58O9 | 622.84 g/mol
Supplier: Thermo Scientific Chemicals J61835MCR
Description
Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases.It is used as an antibacterial, antifungal, antineoplastic and an immunosuppressive. It prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes and is a macrolide antibiotic and potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase).
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases
- It is a macrolide antibiotic, and shows fungicide activity
Application
- Bafilomycin A1 has antibacterial, antifungal, and antineoplastic activity
- It can be immunosuppressive
- It can prevent maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes
- It is a potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase)
Specifications
| Bafilomycin A1 | |
| Oil or Film | |
| Colorless | |
| C35H58O9 | |
| 4730700 | |
| XDHNQDDQEHDUTM-XRCNURIOSA-N | |
| (3Z,5E,7S,8R,9R,11Z,15R,16S)-16-[(2R,3S,4R)-4-[(2S,4S,5R,6S)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one | |
| 133268469 |
| Bafilomycin A1 | |
| 88899-55-2 | |
| 1 mg | |
| MFCD06795130 | |
| Soluble in methanol,ethanol,acetone and chloroform. Insoluble in water. | |
| CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C | |
| 622.84 | |
| 622.83 |
Safety and Handling
GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
H315-H319-H335
RTECSNumber : RN9781000
TSCA : No
storageNote1 : -30° to -10°C
Recommended Storage : Store at -20°C
RUO – Research Use Only