Thermo Scientific™ Arcturus Cellect Laser Capture Microdissection System 

Description

The Arcturus Cellect is a dual laser microdissection capture platform to harvest cells of interest for DNA/RNA and protein research. The Arcturus Cellect platform is designed to be precise and contact-free to help minimize contamination concerns. The Cellect supports all consumables and reagents used by Arcturus legacy instruments. The Arcturus Cellect offers an IR laser and UV laser capability for cell harvesting. The Arcturus Cellect's IR laser is capable of cell harvesting with no damage to the cell's nucleic acid or any degradation to the RNA. Arcturus Cellect UV laser provides the ability to cut through dense tissue as well as the capability of cutting through bone.

The Arcturus Cellect is a dual laser microdissection platform used by researchers to harvest cells of interest for DNA, RNA, and protein research. The Arcturus Cellect offers an IR laser and UV laser capability for cell harvesting. The Arcturus Cellect's IR laser is capable of cell harvesting with no damage to the cell's nucleic acid or any degradation to the RNA. The IR laser also offers single cell capture of cells as small as 10 um in diameter. The Arcturus Cellect UV laser provides the ability to cut through dense tissue as well as the capability of cutting through bone. The Arcturus Cellect laser capture microdissection platform is designed to be precise and contact-free to help minimize contamination concerns. Cap movement is performed by an automated system which reduces human interaction of the CapSure caps which minimizes potential contamination during cell harvesting.

During cell harvesting, the cells to be harvested are marked-up in the software and remains marked throughout the session in order to verify cell locations. The software also calculates the total amount of cells harvested on each CapSure cap. This information as well as any additional notes about the tissue slide and the CapSure cap can be saved by the researcher . A visual inspection of the cells harvested can be performed by placing the CapSure cap in the QC position on the Cellect stage. Images of the tissue before cell harvesting, post cell harvesting, and the cells harvested on the CapSure cap can be saved for documentation purposes. This process provides sample custody and is proof of the cells harvested for downstream analysis.

The Cellect was designed to support proven Arcturus LCM workflows used by Arcturus legacy instruments such as the ArcturusXT and Veritas. The Cellect also supports all consumables and reagents used by Arcturus legacy instruments. Researchers can work with formalin-fixed paraffin-embedded (FFPE) tissue, frozen tissue, and live cells for their experiments on the Arcturus Cellect.

The Arcturus Cellect offers:

• 808 nm IR and 355 nm UV lasers – Used for cell harvesting
• LED brightfield with phase capability – Used to view cell morphology
• 2X, 4X, 10X, 20X, 40X, and 60X objectives standard – Used to view cells as different magnifications
• 10 Megapixel color camera with a 1.67 um X 1.67 um pixel size – Provides sharp resolution for detailed picture quality
• Fully automated stage with 1 um precision – Provides repeatability of movement when harvesting cells
• 3 stage inserts for personalized research – 3 slide stage insert that hold traditional slide size of 75 mm x 26 mm, 2 large format slide stage insert that holds slide size of 75 mm x 50 mm, and a petri dish stage insert that holds a 50 mm x 7 mm petri dish
• Fully automated CapSure™ cap movement system – Provides hands-free capability when moving Arcturus™ Capsure™ caps during research to minimize contamination
• Onboard Intel™ NUC™ PC with Microsoft™ Windows™ 10 OS – Provides powerful integrated PC to operate instrument software and monitor interface
• 32 in. WACOM ultra HD touchscreen monitor option – Possesses ultra-sensitive screen with 8192 sensitivity levels for marking up cell harvesting areas, 5080 LPI resolution, and 1.07 billion display colors (10 bits color)
• Complete line of consumables and reagents - Used to support LCM DNA, RNA, and protein research
• Complete LCM Workflows – Protocols designed to be used for LCM research