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  7. Amlodipine besylate, 98+%

Amlodipine besylate, 98+%

Catalog No. AAJ6216403
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Quantity:
1 g
5 g
25 g
Catalog No. Quantity
AAJ6216403 1 g
AAJ6216406 5 g
AAJ6216414 25 g
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Catalog No. AAJ6216403

Supplier: Thermo Scientific Chemicals J6216403

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Description

An L-type calcium channel antagonist with potent antioxidant activity | CAS: 111470-99-6 | C26H31ClN2O8S | 567.05 g/mol

Amlodipine besylate is used as a dihydropyridine calcium channel blocker. It is also used as an antianginal and antihypertensive. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Amlodipine besylate is used as a dihydropyridine calcium channel blocker. It is also used as an antianginal and antihypertensive. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.

Solubility
Soluble in DMSO (≥20 mg/mL), water (10 mM), chloroform, ethanol (≥14 mg/mL), and methanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Chemical Identifiers

CAS 111470-99-6
Molecular Formula C26H31ClN2O8S
Molecular Weight (g/mol) 567.05
MDL Number MFCD00887594
InChI Key ZPBWCRDSRKPIDG-UHFFFAOYSA-N
Synonym amlodipine besylate, amlodipine besilate, cardiorex, amlodipine benzenesulfonate, istin, amdepin, amdipin, amlodin, amlogard, amlopin
PubChem CID 60496
ChEBI CHEBI:2669
IUPAC Name benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
SMILES CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O

Specifications

Melting Point 195°C to 204°C
Color White
Quantity 1 g
Merck Index 14,491
Solubility Information Soluble in DMSO (?20mg/mL),water (10 mM),chloroform,ethanol (?14mg/mL),and methanol.
Formula Weight 567.05
Percent Purity ≥98%
Physical Form Solid
Chemical Name or Material Amlodipine besylate

Safety and Handling

Hazard Category H302-H315-H319-H335
Hazard Statement GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
RTECSNumber US7967700
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only