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Thermo Scientific Chemicals 4-Epitetracycline hydrochloride, can be used as a secondary standard
4-Epitetracycline hydrochloride, CAS # 23313-80-6, is a degradation product of tetracycline that shows antibiotic activity and can induce the protein biosynthesis inhibition.
Supplier: Thermo Scientific Chemicals 233121000
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- 4-Epitetracycline hydrochloride is a metabolite derived from the degradation of tetracycline compounds and has been shown to display antibiotic activity
- This compound blocks protein synthesis by binding to the 30S ribosomal subunit and interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex
Applications
- This semi-synthesized compound derived from actinomycetes can decrease the activity of the Tet repressor effector in animal models
- In vivo experiments revealed that 4-epitetracycline hydrochloride can induce a toxic response
Specifications
| 4-Epitetracycline hydrochloride | |
| 217.0°C | |
| Authentic | |
| Glass bottle | |
| MFCD00865028 | |
| − 322.00 | |
| Solubility in water: 100g/L. Other solubilities: 100g/L methanol | |
| CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl | |
| 480.89 | |
| 480.89 | |
| Fine Crystalline Powder |
| 23313-80-6 | |
| Yellow | |
| 80% min. (as is,calculated) | |
| C22H24N2O8·HCl | |
| 100 mg | |
| 4-epitetracycline hydrochloride, epitetracycline hydrochloride, 4-epi-tetracycline hydrochloride, quatrimycin hydrochloride, epitetracycline hcl, unii-i7c3edl2yg, i7c3edl2yg, epitetracycline hydrochloride usp, 4r,4as,5as,6s,12as-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride | |
| YCIHPQHVWDULOY-DXDJYCPMSA-N | |
| (4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride | |
| 54686189 | |
| ≥97.0% Total Base (on anhydrous substance), ≥80 wt% (as is, calculated) (HPLC) |
Chemical Identifiers
| 23313-80-6 | |
| 480.89 | |
| YCIHPQHVWDULOY-DXDJYCPMSA-N | |
| 54686189 | |
| CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl |
| C22H24N2O8·HCl | |
| MFCD00865028 | |
| 4-epitetracycline hydrochloride, epitetracycline hydrochloride, 4-epi-tetracycline hydrochloride, quatrimycin hydrochloride, epitetracycline hcl, unii-i7c3edl2yg, i7c3edl2yg, epitetracycline hydrochloride usp, 4r,4as,5as,6s,12as-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochlorideShow More | |
| (4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochlorideShow More |
Safety and Handling
GHS H Statement:
Causes serious eye irritation.
Suspected of damaging the unborn child.
GHS P Statement:
Use personal protective equipment as required.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
GHS Signal Word: Warning
RTECSNumber : QJ1898250
RUO – Research Use Only