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Thermo Scientific Chemicals 4-Epioxytetracycline, 'can be used as secondary standard'
4-Epioxytetracycline, CAS # 14206-58-7, is one of the main oxytetracycline metabolites that show antibacterial activity.
Supplier: Thermo Scientific Chemicals 257711000
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- 4-Epioxytetracycline is a metabolite of the oxytetracycline compound that displays antibacterial activity
- It is the main degradation product derived from the oxytetracycline metabolization and has been detected in some biological samples
- Its mechanism of action has been described to be related to the mitochondrial protein synthesis inhibition
Applications
- In laboratory research it has been described that the treatment with 4-epioxytetracycline decreases the bacterial diversity of the intestinal microbiota and facilitates the proliferation of opportunistic pathogens in salmon
- The use of 4-epioxytetracycline in animal models (wistar rats) resulted in a significant alteration of the gut microbiota and disorders in blood metabolomics
- 4-Epioxytetracycline can be applied as a secondary reference standard during stability studies of oxytetracycline
- 4-epioxytetracycline has been used in research studies to evaluate the degradation pathway and products of tetracyclines
Specifications
| 4-Epioxytetracycline | |
| 14206-58-7 | |
| 100.0 | |
| Beige-Green to Brown | |
| 80% min. (as is,calculated) | |
| C22H24N2O9 | |
| 100 mg | |
| − 247.00 | |
| Solubility in water: 0.5g/L. Other solubilities: 3.6g/L methanol | |
| CC1(C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O | |
| 460.43 | |
| 460.43 | |
| Powder |
| 97% | |
| 96.0 | |
| 168.0°C | |
| Authentic | |
| Glass bottle | |
| MFCD00062825 | |
| 10, 6846 | |
| 4-epioxytetracyline, unii-73von8sry5, 4-epioxytetracycline, 73von8sry5, 4r,4ar,5s,5ar,6s,12as-4-dimethylamino-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide, hydroxy quatrimycin, oxytetracycline dihydrate specified impurity a ep, oxytetracycline hydrochloride specified impurity a ep, 4r,4ar,5s,5ar,6s,12as-4-dimethylamino-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, 2-naphthacenecarboxamide, 4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, 4r,4ar,5s,5ar,6s,12as | |
| OWFJMIVZYSDULZ-DVJPNYBFSA-N | |
| (4R,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide | |
| 54678403 | |
| ≥97.0% Total Base (on anhydrous substance), ≥80 wt% (as is, calculated) (HPLC) |
Chemical Identifiers
| 14206-58-7 | |
| 460.43 | |
| OWFJMIVZYSDULZ-DVJPNYBFSA-N | |
| 54678403 | |
| CC1(C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O |
| C22H24N2O9 | |
| MFCD00062825 | |
| 4-epioxytetracyline, unii-73von8sry5, 4-epioxytetracycline, 73von8sry5, 4r,4ar,5s,5ar,6s,12as-4-dimethylamino-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide, hydroxy quatrimycin, oxytetracycline dihydrate specified impurity a ep, oxytetracycline hydrochloride specified impurity a ep, 4r,4ar,5s,5ar,6s,12as-4-dimethylamino-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, 2-naphthacenecarboxamide, 4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, 4r,4ar,5s,5ar,6s,12asShow More | |
| (4R,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamideShow More |
Safety and Handling
GHS H Statement
Causes serious eye irritation.
Suspected of damaging the unborn child.
GHS P Statement
Wash face,hands and any exposed skin thoroughly after handling.
Wear protective gloves/protective clothing/eye protection/face protection.
Obtain special instructions before use.
IF exposed or concerned: Get medical
GHS Signal Word: Warning
Recommended Storage : 4°C
RUO – Research Use Only