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Thermo Scientific Chemicals 2'-Deoxyuridine, 98+%

Catalog No. aaa1602606
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Catalog No. AAA1602606 Supplier Thermo Scientific Chemicals Supplier No. A1602606
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Description

CAS: 951-78-0 | C9H12N2O5 | 228.20 g/mol

2'-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2?-Deoxyuridines used as labeling substrates include chloro-2?-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2?-deoxyuridine include 5-ethynyl-2?-deoxyuridine (DdU) and 5-hydroxymethyl-2?-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2′-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2′-Deoxyuridines used as labeling substrates include chloro-2′-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2′-deoxyuridine include 5-ethynyl-2′-deoxyuridine (DdU) and 5-hydroxymethyl-2′-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.

Solubility
Soluble in water.

Notes
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is sensitive to air.

Chemical Identifiers

CAS 951-78-0
Molecular Formula C9H12N2O5
Molecular Weight (g/mol) 228.20
MDL Number MFCD00006527
InChI Key MXHRCPNRJAMMIM-SHYZEUOFSA-N
Synonym 2'-deoxyuridine, deoxyuridine, uracil deoxyriboside, 2-deoxyuridine, 1-2r,4s,5r-4-hydroxy-5-hydroxymethyl tetrahydrofuran-2-yl pyrimidine-2,4 1h,3h-dione, deoxyribose uracil, uridine, 2'-deoxy, 2'-desoxyuridine, unii-w78i7ay22c, ccris 2832
PubChem CID 13712
ChEBI CHEBI:16450
IUPAC Name 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
SMILES OC[C@H]1O[C@H](C[C@@H]1O)N1C=CC(=O)NC1=O

Specifications

Melting Point 164°C to 167°C
Quantity 5 g
Beilstein 24433
Sensitivity Air Sensitive
Merck Index 14,2910
Solubility Information Soluble in water.
Optical Rotation +52° (c=1.1 in 1N NaOH)
Formula Weight 228.21
Percent Purity 99%
Chemical Name or Material 2'-Deoxyuridine

Safety and Handling

EINECSNumber 213-455-7
RTECSNumber YU7490000
TSCA Yes
Recommended Storage Ambient temperatures

RUO – Research Use Only