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2-(2-Bromoethyl)-1,3-dioxane, 98%
Description
2-(2-Bromoethyl)-1,3-dioxane, Provides a useful means of introducing a masked β-formylethyl group. In comparison with the corresponding dioxolane (following entry), the dioxane is more stable to acid, and the Grignard is thermally stable. Reaction of the Grignard with an acid chloride gives the ketone in high yield without further reaction to the tertiary alcohol. Subsequent hydrolysis of the 1,3-dioxane gives the -ketoaldehyde. It is also used as a pharmaceutical intermediate.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
2-(2-Bromoethyl)-1,3-dioxane, Provides a useful means of introducing a masked ß-formylethyl group. In comparison with the corresponding dioxolane (following entry), the dioxane is more stable to acid, and the Grignard is thermally stable. Reaction of the Grignard with an acid chloride gives the ketone in high yield without further reaction to the tertiary alcohol. Subsequent hydrolysis of the 1,3-dioxane gives the -ketoaldehyde. It is also used as a pharmaceutical intermediate.
Solubility
It is not soluble in water but soluble in organic solvent such as ethanol.
Notes
Air, Heat sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.
Specifications
Specifications
| Density | 1.434 |
| Boiling Point | 67°C to 70°C (3 mmHg) |
| Flash Point | 96°C (204°F) |
| Refractive Index | 1.482 |
| Quantity | 10 g |
| Beilstein | 1421628 |
| Solubility Information | It is not soluble in water but soluble in organic solvent such as ethanol. |
| IUPAC Name | 2-(2-bromoethyl)-1,3-dioxane |
| Formula Weight | 195.06 |
| Percent Purity | 98% |
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Safety and Handling
| Hazard Category | H315-H319-H341 |
| Hazard Statement | GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. |
| Precautionary Statement | P201-P202-P264b-P280i-P281-P302+P352-P305+P351+P338-P308+P313-P332+P313-P362-P501c |
| EINECSNumber | 251-716-7 |
| TSCA | Yes |
| Recommended Storage | Keep cold; Store under Nitrogen |
RUO – Research Use Only