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  7. 1-Methylpiperazine, 98+%

1-Methylpiperazine, 98+%

Catalog No. p-7081039
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Catalog No. Quantity
AAA10837AE 100 mL
AAA10837AP 500 mL
AAA108370F 2500 mL
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Catalog No. AAA10837AE

Supplier: Thermo Scientific Chemicals A10837AE

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Description

CAS: 109-01-3 | C5H12N2 | 100.165 g/mol

1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

Solubility
Miscible with water and methanol.

Notes
Hygroscopic. Moisture sensitive. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents and carbon dioxide.

Chemical Identifiers

CAS 109-01-3
Molecular Formula C5H12N2
Molecular Weight (g/mol) 100.165
MDL Number MFCD00005966
InChI Key PVOAHINGSUIXLS-UHFFFAOYSA-N
Synonym n-methylpiperazine, piperazine, 1-methyl, 4-methylpiperazine, 1-methyl-piperazine, n-methyl piperazine, 1-methyl piperazine, methylpiperazine, n-methyl-piperazine, n-methylpiperazin, 1-methylpyperazine
PubChem CID 53167
IUPAC Name 1-methylpiperazine
SMILES CN1CCNCC1

Specifications

Melting Point -6°C
Density 0.903
Boiling Point 137°C to 139°C
Flash Point 34°C (93°F)
Odor Amine-like
Refractive Index 1.4655
Quantity 100 mL
UN Number UN2734
Beilstein 102724
Sensitivity Air Sensitive
Solubility Information Miscible with water and methanol.
Formula Weight 100.17
Percent Purity ≥98%
Chemical Name or Material 1-Methylpiperazine
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Safety and Handling

Hazard Category H226-H302+H312+H332-H314-H317-H335
Hazard Statement GHS H Statement
H331-H314-H318-H226-H302-H312
Toxic if inhaled.
Causes severe skin burns and eye damage.
Causes serious eye damage.
Flammable liquid and vapor.
Harmful if swallowed.
Harmful in contact with skin.
Precautionary Statement P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P272-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P333+P313-P363-P370+P378q-P501c
DOTInformation Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S.
EINECSNumber 203-639-5
RTECSNumber TM1225000
TSCA Yes
Recommended Storage Ambient temperatures; Store under Argon

RUO – Research Use Only