Please login to your online account to display your discounted pricing

ZO-1 Rat, Clone: R26.4C, eBioscience™

Rat Monoclonal Antibody

$143.55 - $346.55

Specifications

Antigen ZO-1
Clone R26.4C
Host Species Rat
Gene Alias Tight Junction Protein 1
Species Reactivity Canine, Mouse, Rat
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122861

 
affymetrix
14977680
25μg Each for $143.55

501122862

 
affymetrix
14977682
100μg Each for $346.55
Description & Specifications

Specifications

Antigen ZO-1
Clone R26.4C
Host Species Rat
Gene Alias Tight Junction Protein 1
Species Reactivity Canine, Mouse, Rat
Applications Immunocytochemistry
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody R26.4C recognizes the tight junction protein 1, ZO-1 (zona occludens) of rat, mouse, canine, and porcine. ZO-1 is a member of the MAGUK family of tight junction associated scaffolding proteins, each containing a PDZ, SH3 and guanylate kinase-like (GUK) domain. ZO-1 is an integral member of the tight junction complex which forms a barrier to paracellular movement of substances, separating apical and basolateral fluids in relation to the epithelial cell layer. ZO-1 forms complexes with family members ZO-2, ZO-3, as well as occludin, cingulin, claudin-1-8, actin, alpha-catenin, the Ras-effector molecule AF-6, ZONAB, Apg-2, and the junctional adhesion molecules (JAM)-A-C. ZO-1 is thought to anchor the actin cytoskeleton to the tight junction. ZO-1 and ZO-2 have been shown to regulate cell cycle and proliferation with recent evidence highlighting the down-regulation of ZO-1 and ZO-2 with cancer progression.