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Tocris™ ZM 336372

Potent, selective c-Raf inhibitor

Manufacturer:  Tocris™ RDS132110

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Catalog No. 132110


 

Disclaimers:

For Research Use Only


Specifications

Description

Inhibitor, Enzyme; Tocris; ZM 336372; Potent, selective c-Raf inhibitor; Molecular wt: 389.45; CAS Number: 208260-29-1; Formula: C23H23N3O3; Purity:>99; 10mg

Potent, selective inhibitor of c-Raf in vitro (IC50 = 70nM for inhibition of human c-Raf). Shows 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC50 = 2μM). Selective over 17 other protein kinases including PKA, PKC, p42 MAPK, CDK1 and SAPK1/JNK (up to 50μM). Also available as part of the MAPK Cascade Inhibitor Tocriset™.
  • Chemical Name: 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide
  • Formula: C23H23N3O3
  • CAS Number: 208260-29-1
  • Solubility: Soluble to 100mM in DMSO
  • Purity: >99
Description & Specifications

Specifications

ZM 336372
>99
10mg
ZM 336372
389.45