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ZEB1 Mouse, Clone: 3G6, eBioscience™

Mouse Monoclonal Antibody

$143.55 - $361.05

Specifications

Antigen ZEB1
Clone 3G6
Host Species Mouse
Gene Alias TCF8, AREB6
Species Reactivity Human, Mouse, Rat
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122809

 
affymetrix
14974180
25μg Each for $143.55

501122810

 
affymetrix
14974182
100μg Each for $361.05
Description & Specifications

Specifications

Antigen ZEB1
Clone 3G6
Host Species Mouse
Gene Alias TCF8, AREB6
Species Reactivity Human, Mouse, Rat
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody 3G6 recognizes human, mouse, and rat ZEB1. ZEB1, or zinc finger E-box binding homeobox 1, is also known as Transcription Factor 8 (TCF8), Negative Regulator of IL2, and AREB6. ZEB1 acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. ZEB1 also regulates expression of the genes E-cadherin, BCL6, ATP1A1, and RCOR1 through binding to multiple enhancer boxes (E-boxes). ZEB1 promotes epithelial mesenchymal transition (EMT) and invasion of various types of cancers, such as colorectal, breast, pancreatic, lung, and gallbladder. In normal tissues, ZEB1 is expressed in tissues undergoing differentiation such as T cell and skeletal differentiation. Mutations in ZEB1 have been associated with corneal dystrophy.