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Thermo Scientific™ Lab Vision™ XRCC1 (X-Ray Repair Cross Complementing Protein 1) Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ XRCC1 (X-Ray Repair Cross Complementing Protein 1) Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS434P1ABX

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Catalog No. MS434P1ABX

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Description & Specifications

Specifications

Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Immunogen Recombinant human XRCC1 protein
Cross Reactivity Human
Cross Reactivity Rat
Format Concentrated
Quantity 100µL
Clone 33-2-5
Host Species Mouse
Antigen XRCC1 (X-Ray Repair Cross Complementing Protein1) Ab-1
Isotype IgG2b
Regulatory Status RUO
Formulation Ab without BSA/Azide (Frozen)
Research Discipline DNA Repair
Type Primary
Concentration 1mg/mL
Conjugate Unlabeled
Classification Monoclonal

Provide accurate, reproducible results with the Thermo Scientific™ XRCC1 (X-Ray Repair Cross Complementing Protein 1) Ab-1, Mouse Monoclonal Antibody.

X-Ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNA ligase III through the C-terminal 96 amino acids and to DNA polymerase β through the N-terminal half. In testis XRCC1 is expressed at high levels. Cells with a mutation of this gene exhibit decreased single strand break repair and reduced recombination repair. They show increased double strand breaks, and sister chromatid exchange is increased up to 10-fold. The XRCC1 might serve as a scaffold protein during base excision-repair.

Host Species: Mouse

Clone: 33-2-5

Isotype: IgG2b

Species Reactivity: Human and Rat. Others not known.

Epitope: Not determined

Immunogen: Recombinant human XRCC1 protein

Molecular Weight: 85kDa

Positive Control: Ls174T, HT29 or HeLa cells; normal testis

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Native verified)

Note:

USA: RUO; Int'l: RUO