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Thermo Scientific™ Lab Vision™ XRCC1 (X-Ray Repair Cross Complementing Protein 1) Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ XRCC1 (X-Ray Repair Cross Complementing Protein 1) Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS434P1ABX

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Catalog No. MS434P1ABX

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Description & Specifications

Specifications

Antigen XRCC1 (X-Ray Repair Cross Complementing Protein1) Ab-1
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone 33-2-5
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Rat
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Mouse
Immunogen Recombinant human XRCC1 protein
Isotype IgG2b
Quantity 100µL
Regulatory Status RUO
Research Discipline DNA Repair
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ XRCC1 (X-Ray Repair Cross Complementing Protein 1) Ab-1, Mouse Monoclonal Antibody.

X-Ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNA ligase III through the C-terminal 96 amino acids and to DNA polymerase β through the N-terminal half. In testis XRCC1 is expressed at high levels. Cells with a mutation of this gene exhibit decreased single strand break repair and reduced recombination repair. They show increased double strand breaks, and sister chromatid exchange is increased up to 10-fold. The XRCC1 might serve as a scaffold protein during base excision-repair.

Host Species: Mouse

Clone: 33-2-5

Isotype: IgG2b

Species Reactivity: Human and Rat. Others not known.

Epitope: Not determined

Immunogen: Recombinant human XRCC1 protein

Molecular Weight: 85kDa

Positive Control: Ls174T, HT29 or HeLa cells; normal testis

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Native verified)

Note:

USA: RUO; Int'l: RUO