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Thermo Scientific™ Lab Vision™ XPF Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ XPF Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS1381P1ABX

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Catalog No. MS1381P1ABX

  • / Each
 

Description & Specifications

Specifications

Host Species Mouse
Regulatory Status RUO
Antigen XPF Ab-1
Immunogen Recombinant human XPF protein
Cross Reactivity Human
Quantity 100µL
Format Concentrated
Applications Immunohistochemistry (Paraffin)
Applications Western Blotting
Clone 219
Isotype IgG2
Type Primary
Concentration 1mg/mL
Classification Monoclonal
Conjugate Unlabeled
Research Discipline DNA Repair
Formulation Ab without BSA/Azide (Frozen)

Provide accurate, reproducible results with the Thermo Scientific™ XPF Ab-1, Mouse Monoclonal Antibody.

The structure-specific ERCC1/XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV-induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross-links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision.

Host Species: Mouse

Clone: 219

Isotype: IgG2/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant human XPF protein

Molecular Weight: ∽110kDa

Positive Control: MCF-7 cells or human tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting

Note:

USA: RUO; Int'l: RUO