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Thermo Scientific™ Lab Vision™ XPA Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ XPA Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS650P1ABX

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Catalog No. MS650P1ABX

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Description & Specifications

Specifications

Antigen XPA Ab-1
Applications Western Blotting
Classification Monoclonal
Clone 12F5
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Mouse
Immunogen Recombinant human XPA protein
Isotype IgG2a kappa
Quantity 100µL
Regulatory Status RUO
Research Discipline DNA Repair
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ XPA Ab-1, Mouse Monoclonal Antibody.

The XPA (xeroderma pigmentosum group A) protein specifically recognizes the UV-or chemically damaged DNA lesions, and triggers the nucleotide excision repair process. XPA binds to the replication protein A (RPA) or the excision repair cross complementing 1 protein (ERCC1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a > 2000 fold increased risk to develop skin cancer at sun-exposed areas.

Host Species: Mouse

Clone: 12F5

Isotype: IgG2a/k

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant human XPA protein

Molecular Weight: ∽40kDa

Positive Control: Ls174T or MCF-7 cells or human tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting

Note:

USA: RUO; Int'l: RUO