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Thermo Scientific™ Lab Vision™ XPA Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ XPA Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS650P1ABX

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Catalog No. MS650P1ABX

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Description & Specifications

Specifications

Applications Western Blotting
Quantity 100µL
Cross Reactivity Human
Immunogen Recombinant human XPA protein
Isotype IgG2a kappa
Clone 12F5
Antigen XPA Ab-1
Regulatory Status RUO
Host Species Mouse
Format Concentrated
Conjugate Unlabeled
Formulation Ab without BSA/Azide (Frozen)
Type Primary
Research Discipline DNA Repair
Classification Monoclonal
Concentration 1mg/mL

Provide accurate, reproducible results with the Thermo Scientific™ XPA Ab-1, Mouse Monoclonal Antibody.

The XPA (xeroderma pigmentosum group A) protein specifically recognizes the UV-or chemically damaged DNA lesions, and triggers the nucleotide excision repair process. XPA binds to the replication protein A (RPA) or the excision repair cross complementing 1 protein (ERCC1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a > 2000 fold increased risk to develop skin cancer at sun-exposed areas.

Host Species: Mouse

Clone: 12F5

Isotype: IgG2a/k

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant human XPA protein

Molecular Weight: ∽40kDa

Positive Control: Ls174T or MCF-7 cells or human tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting

Note:

USA: RUO; Int'l: RUO