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Thermo Scientific™ Lab Vision™ von Hippel-Lindau (vHL) Protein Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ von Hippel-Lindau (vHL) Protein Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS690P1ABX

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Catalog No. MS690P1ABX

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Description & Specifications

Specifications

Antigen von Hippel-Lindau (vHL) Protein Ab-1
Classification Monoclonal
Clone Ig33
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Format Concentrated
Host Species Murine
Immunogen A recombinant protein containing aa 1-213 of human VHL
Isotype IgG2a kappa
Quantity 100μL
Regulatory Status RUO
Research Discipline Cancer and Tumor Biology
Type Primary
Monoclonal or Polyclonal Monoclonal
Target Species Human
Target Species Murine

Provide accurate, reproducible results with the Thermo Scientific™ von Hippel-Lindau (vHL) Protein Ab-1, Mouse Monoclonal Antibody.

Molecular genetic studies suggest that VHL is a tumor-suppressor gene. Alterations in the von Hippel-Lindau (VHL) gene are correlated with a diverse group of neoplasms including hemangioblastoma, clear cell renal carcinoma (RCC), and pheochromocytoma. Two transcriptional elongation factors, Elongin B and C, are shown to bind in vitro and in vivo to a short, colinear region of the VHL protein (pVHL) that is frequently mutated in human tumors. It is proposed that pVHL functions in vivo as a negative regulator of transcription elongation.

Host Species: Mouse

Clone: Ig33

Isotype: IgG1/κ

Species Reactivity: Human and Mouse. Others not known.

Epitope: aa 1-54

Immunogen: A recombinant protein containing aa 1-213 of human vHL

Molecular Weight: 30kDa

Positive Control: Kidney

Cellular Localization: Cytoplasmic Ab-1 does not recognize the truncated form of VHL protein.

Note:

USA: RUO; Int'l: RUO