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Thermo Scientific™ Lab Vision™ von Hippel-Lindau (vHL) Protein Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ von Hippel-Lindau (vHL) Protein Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS690P1ABX

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Catalog No. MS690P1ABX

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Description & Specifications

Specifications

Antigen von Hippel-Lindau (vHL) Protein Ab-1
Classification Monoclonal
Clone Ig33
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Format Concentrated
Host Species Mouse
Immunogen A recombinant protein containing aa 1-213 of human VHL
Isotype IgG2a kappa
Quantity 100µL
Regulatory Status RUO
Research Discipline Cancer and Tumor Biology
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ von Hippel-Lindau (vHL) Protein Ab-1, Mouse Monoclonal Antibody.

Molecular genetic studies suggest that VHL is a tumor-suppressor gene. Alterations in the von Hippel-Lindau (VHL) gene are correlated with a diverse group of neoplasms including hemangioblastoma, clear cell renal carcinoma (RCC), and pheochromocytoma. Two transcriptional elongation factors, Elongin B and C, are shown to bind in vitro and in vivo to a short, colinear region of the VHL protein (pVHL) that is frequently mutated in human tumors. It is proposed that pVHL functions in vivo as a negative regulator of transcription elongation.

Host Species: Mouse

Clone: Ig33

Isotype: IgG1/κ

Species Reactivity: Human and Mouse. Others not known.

Epitope: aa 1-54

Immunogen: A recombinant protein containing aa 1-213 of human vHL

Molecular Weight: 30kDa

Positive Control: Kidney

Cellular Localization: Cytoplasmic Ab-1 does not recognize the truncated form of VHL protein.

Note:

USA: RUO; Int'l: RUO