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VEGF Receptor 1 (Flt1) Rat anti-Human, Clone: 7A6, eBioscience™

Rat Monoclonal Antibody

$129.05 - $332.05

Specifications

Antigen VEGF Receptor 1 (Flt1)
Clone 7A6
Host Species Rat
Gene Alias VEGF-R1, Flt-1, FMS-like tyrosine kinase 1, vascular endothelial growth factor receptor
Species Reactivity Human
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013335

 
affymetrix
14593680
25μg Each for $129.05

5013336

 
affymetrix
14593682
100μg Each for $332.05
Description & Specifications

Specifications

Antigen VEGF Receptor 1 (Flt1)
Clone 7A6
Host Species Rat
Gene Alias VEGF-R1, Flt-1, FMS-like tyrosine kinase 1, vascular endothelial growth factor receptor
Species Reactivity Human
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This 7A6 monoclonal antibody recognizes human VEGFR1 (vascular endothelial growth factor receptor 1, fms-like tyrosine kinase 1, FLT1). It is directed against the extracellular domain and can recognize both membrane-bound and soluble forms of VEGFR1, with approximate molecular weights of 180kDa and 90 kDa, respectively. Mice lacking expression of VEGFR1 have disorganized vasculature and die in utero, however angiogenesis does not require the tyrosine kinase activity of VEGFR1 as expression of a membrane-bound form lacking the tyrosine kinase domain allows normal development. Although fertile and viable, mice lacking the tyrosine kinase domain of VEGFR1 do have a defect in the migration of macrophages. The soluble form of VEGFR1 can be detected in the serum of normal patients, and elevated levels of soluble VEGFR1 in pregnant women is associated with preeclampsia. Several tumor cell lines have been reported to express membrane-bound VEGFR1, including malignancies of hematopoietic origin.