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Invitrogen™ ULK2 Recombinant Human Protein DFS Item

ULK2 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. Recombinant human ULK2 (1-478) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Manufacturer:  Invitrogen™ LSPV6435

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Catalog No. PV6435



Description

Description

Mammalian Atg13 binds ULK2 and mediates the interaction of the ULK protein with FIP200. The binding of Atg13 stabilizes and activates ULK and facilitates the phosphorylation of FIP200 by ULK. The ULK-Atg13-FIP200 complex is a direct target of mTOR and important regulator of autophagy in response to mTOR signalling. Yeast 2-hybrid assays showed the C-terminus of ULK2 binds the C-terminus of SynGAP, a negative regulator of Ras that is associated with neural development.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use
Specifications

Specifications

Target & Lead Identification & Validation|Kinase Biology|Kinase Proteins & Expression Reagents|Protein Biology|Enzyme & Protein Activity Assays|Kinase Activity|Protein Assays and Analysis|Industrial & Applied Science|Pharma & Biopharma
81.3kDa
Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.
Kinase Assay
Human
GST Tag
50mM Tris-HCl pH 7.5, 150mM NaCl, 0.25mM DTT, 10mM glutathione, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol
1mg
Unc51.2, KIAA0623
aa 1-478. Contains V370M SNP
Yes
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