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Ub-K63 Mouse anti-Human, Clone: HWA4C4, eBioscience™

Mouse Monoclonal Antibody

$117.48 - $328.68

Specifications

Antigen Ub-K63
Clone HWA4C4
Host Species Murine
Gene Alias K63-linked polyubiquitin, Lysine63-linked poly ubiquitin chain
Applications Western Blot
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013453 Life Technologies
LS14607780
25μg Each for $117.48
5013454 Life Technologies
LS14607782
100μg Each for $328.68
Specifications

Description

Ubiquitin is a highly conserved 76kDa protein which is ligated to many proteins in both monomeric and polymeric forms. Ubiquitin polymers (polyubiquitin) can be found in several varieties depending on which of its 7 lysine residues is the site of ligation. The two most common polymer chains are linked via an isopeptide bond between glycine-76 and either lysine-48 (K-48) or lysine-63 (K-63). K-48-linked polyubiquitination typically results in targeting the protein to the 26S proteosome resulting in proteolysis, although recently exceptions to this have been observed. In contrast, K-63-linked polyubiquitination results in signals related to intracellular trafficking, cell signaling, ribosomal biogenesis, and DNA damage repair. There are also reports that K63-linked polyubiquitin is involved in proteosome-independent proteolysis via autophagy.

HWA4C4 reacts specifically with the isopeptide linkage region of lysine-63-linked polyubiquitin. It does not react with other forms of ubiquitin including ubiquitin monomer and lysine-48-linked chains.
Description & Specifications

Specifications

Ub-K63
Murine
Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
HWA4C4
K63-linked polyubiquitin, Lysine63-linked poly ubiquitin chain
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer