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Ub-K63 Mouse anti-Human, Clone: HWA4C4, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $361.05

Specifications

Antigen Ub-K63
Clone HWA4C4
Host Species Mouse
Gene Alias K63-linked polyubiquitin, Lysine63-linked poly ubiquitin chain
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013453

 
affymetrix
14-6077-80
25μg Each for $129.05

5013454

 
affymetrix
14-6077-82
100μg Each for $361.05
Description & Specifications

Specifications

Antigen Ub-K63
Clone HWA4C4
Host Species Mouse
Gene Alias K63-linked polyubiquitin, Lysine63-linked poly ubiquitin chain
Species Reactivity Human
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

Ubiquitin is a highly conserved 76kDa protein which is ligated to many proteins in both monomeric and polymeric forms. Ubiquitin polymers (polyubiquitin) can be found in several varieties depending on which of its 7 lysine residues is the site of ligation. The two most common polymer chains are linked via an isopeptide bond between glycine-76 and either lysine-48 (K-48) or lysine-63 (K-63). K-48-linked polyubiquitination typically results in targeting the protein to the 26S proteosome resulting in proteolysis, although recently exceptions to this have been observed. In contrast, K-63-linked polyubiquitination results in signals related to intracellular trafficking, cell signaling, ribosomal biogenesis, and DNA damage repair. There are also reports that K63-linked polyubiquitin is involved in proteosome-independent proteolysis via autophagy.

HWA4C4 reacts specifically with the isopeptide linkage region of lysine-63-linked polyubiquitin. It does not react with other forms of ubiquitin including ubiquitin monomer and lysine-48-linked chains.