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Tyrphostin A23, 99%, Thermo Scientific Chemicals
Potent inhibitor of EGF receptor kinase activity
$146.49 - $569.37
Chemical Identifiers
| CAS | 118409-57-7 |
|---|---|
| Molecular Formula | C10H6N2O2 |
| Molecular Weight (g/mol) | 186.17 |
| MDL Number | MFCD00133899 |
| InChI Key | VTJXFTPMFYAJJU-UHFFFAOYSA-N |
| Synonym | tyrphostin 23, tyrphostin a23, 3,4-dihydroxybenzylidene malononitrile, tyrphostin ag18, tyrphostin rg50810, unii-rv0gcd31oj, 2-3,4-dihydroxyphenyl methylidene propanedinitrile, 2-3,4-dihydroxybenzylidene malononitrile, alpha-cyano-3,4-dihydroxy cinnamonitrile, propanedinitrile,2-3,4-dihydroxyphenyl methylene |
| PubChem CID | 2052 |
| IUPAC Name | 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile |
| SMILES | C1=CC(=C(C=C1C=C(C#N)C#N)O)O |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ60308LB0
|
Thermo Scientific Chemicals
J60308LB0 |
5 mg |
Each for $146.49
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AAJ60308MA
|
Thermo Scientific Chemicals
J60308MA |
10 mg |
Each for $248.75
|
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AAJ60308MB
|
Thermo Scientific Chemicals
J60308MB |
25 mg |
Each for $569.37
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Description
Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsTyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.
Solubility
Soluble in DMSO, ethanol, or DMF
Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, acids, heat.
Chemical Identifiers
| 118409-57-7 | |
| 186.17 | |
| VTJXFTPMFYAJJU-UHFFFAOYSA-N | |
| 2052 | |
| C1=CC(=C(C=C1C=C(C#N)C#N)O)O |
| C10H6N2O2 | |
| MFCD00133899 | |
| tyrphostin 23, tyrphostin a23, 3,4-dihydroxybenzylidene malononitrile, tyrphostin ag18, tyrphostin rg50810, unii-rv0gcd31oj, 2-3,4-dihydroxyphenyl methylidene propanedinitrile, 2-3,4-dihydroxybenzylidene malononitrile, alpha-cyano-3,4-dihydroxy cinnamonitrile, propanedinitrile,2-3,4-dihydroxyphenyl methylene | |
| 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile |
Specifications
| 118409-57-7 | |
| C10H6N2O2 | |
| 5 mg | |
| Soluble in DMSO, ethanol, or DMF | |
| C1=CC(=C(C=C1C=C(C#N)C#N)O)O | |
| 186.17 | |
| 186.17 | |
| Powder |
| Brown to Yellow | |
| MFCD00133899 | |
| tyrphostin 23, tyrphostin a23, 3,4-dihydroxybenzylidene malononitrile, tyrphostin ag18, tyrphostin rg50810, unii-rv0gcd31oj, 2-3,4-dihydroxyphenyl methylidene propanedinitrile, 2-3,4-dihydroxybenzylidene malononitrile, alpha-cyano-3,4-dihydroxy cinnamonitrile, propanedinitrile,2-3,4-dihydroxyphenyl methylene | |
| VTJXFTPMFYAJJU-UHFFFAOYSA-N | |
| 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile | |
| 2052 | |
| 99% | |
| Tyrphostin A23 |
Safety and Handling
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only