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Alfa Aesar™ Tyrphostin A23, 99%

Potent inhibitor of EGF receptor kinase activity

Chemical Identifiers

Chemical Name or Material Tyrphostin A23
CAS 118409-57-7
Molecular Formula C10H6N2O2
Formula Weight 186.17
MDL Number MFCD00133899
Synonym Tyrphostin AG-18; 2-(3,4-Dihydroxybenzylidene)malononitrile
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAJ60308LB0

  SDS
alfa aesar™
J60308LB0
5mg CALL N/A N/A
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Description & Specifications

Specifications

Formula Weight 186.17
Chemical Name or Material Tyrphostin A23
CAS 118409-57-7
MDL Number MFCD00133899
Assay 99%
Synonym Tyrphostin AG-18; 2-(3,4-Dihydroxybenzylidene)malononitrile
Physical Form Powder
Recommended Storage −30° to −10°C
Quantity 5mg
Color Yellow to Pale Brown
Solubility Information Soluble in DMSO, ethanol, or DMF
Molecular Formula C10H6N2O2

Applications
Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.

Solubility
Soluble in DMSO, ethanol, or DMF

Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, acids, heat.

Safety and Handling

−30° to −10°C