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TSLP Receptor Mouse anti-Human, APC, Clone: 1A6, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $433.55

Specifications

Antigen TSLP Receptor
Clone eBio1A6 (1A6)
Host Species Murine
Gene Alias thymic stromal derived lymphopoietin receptor, CRLF-2
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501123134 Life Technologies
LS17549941
25 Tests Each for $172.55
501129286 Life Technologies
LS17549942
100 Tests Each for $433.55
Specifications

Description

The eBio1A6 monoclonal antibody reacts with human thymic stromal-derived lymphopoietin receptor (TSLPR). TSLPR is an approximately 50kDa protein with significant similarity to the common gamma-chain. TSLPR complexes with IL-7R alpha (CD127) to form the high affinity receptor that binds thymic stromal-derived lymphopoietin (TSLP). Human TSLPR is expressed by monocytes and CD11c+ dendritic cells, and TSLP binding induces the expression of the Th2 cell-attracting chemokines CCL17 and CCL22. Furthermore, the TSLPR-induced activation of dendritic cells indirectly results in the increased secretion of Th cytokines IL-4, -5 and -13, which may be necessary for the regulation of CD4+ T cell homeostasis. In mice, deficiency of TSLPR has no effect on lymphocyte numbers, whereas double deficiency of TSLPR and common gamma-chain results in fewer lymphocytes than seen in mice deficient in the common gamma-chain alone. The eBio1A6 monoclonal antibody is able to cross-block binding of another anti-human TSLPR monoclonal antibody, 1D8.
Description & Specifications

Specifications

TSLP Receptor
Murine
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
eBio1A6 (1A6)
thymic stromal derived lymphopoietin receptor, CRLF-2
Flow Cytometry
Allophycocyanin
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.06μg)/test