missing translation for 'onlineSavingsMsg'
Learn More
Please login to your online account to display your discounted pricing

TSLP Rat anti-Mouse, Clone: eBio28F12 (28F12), Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$157.08 - $473.88

Specifications

Antigen TSLP
Clone eBio28F12 (28F12)
Host Species Rat
Gene Alias thymic stromal derived lymphopoietin
Species Reactivity Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122961 Life Technologies
LS16549185
500μg Each for $473.88
5014565 Life Technologies
LS16549182
100μg Each for $157.08
Specifications

Description

The monoclonal antibody eBio28F12 reacts with and inhibits the bioactivity of mouse TSLP. Thymic Stromal-Derived Lymphopoetin (TSLP) was first identified in the tissue culture supernatant of a thymic stromal cell line as a growth factor capable of inducing proliferation and differentiation of pre-B cells. It was later found to be closely related to another stromal cytokine, IL-7, with which it shares overlapping functions. Along with its proliferative effects on B cells, TSLP induces dendritic cells to support the differentiation of naïve T cells towards the Th2 lineage and may also be involved in the development of CD4+CD25+ regulatory T cells. The receptor for TSLP is heterodimeric and shares one subunit, IL-7Rα, with IL-7 and other members of the family, while the TSLPR subunit is unique to TSLP.

TSLP expression can be induced by a variety of inflammatory cytokines and TLR ligands. Expression is regulated by NF-κB and has been detected in epithelial cells, stromal cells, and basophils. Elevated levels of TSLP are associated with asthma and atopic dermatitis, which are both Th2-mediated inflammatory conditions. It is believed that chronic overexpression of TSLP may result in increased sensitivity to allergens, resulting in susceptibility to these conditions.

Description & Specifications

Specifications

TSLP
Rat
Mouse
RUO
Purified
Primary
aqueous buffer, no sodium azide
eBio28F12 (28F12)
thymic stromal derived lymphopoietin
Cytokine Neutralization
Unlabeled
Store at 2-8°C.
Monoclonal
1mg/mL