Trimethylsilyl azide is used as an azidonation reagent for amines, amides, aldehydes and ketones. It is involved in the preparation of alfa- and beta-siloxy azides from carbonyl compounds and epoxides. It is also used in the preparation of heterocyclic compounds and also acts as an effective substitute for hydrazoic acid. Further, it is used in the Oseltamivir total synthesis.
Miscible with toluene, dichloromethane, diethyl ether and most organic solvents.
Moisture sensitive. Store in a cool place. Incompatible with strong oxidizing agents and strong acids.
|95° to 99°C|
Safety and Handling
GHS H Statement
Highly flammable liquid and vapor.
Fatal if swallowed.
Fatal in contact with skin.
Fatal if inhaled.
GHS P Statement
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
Specific treatment is urgent (see label).
Remove/Take off immediately all contaminated clothing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
DOTInformation : Transport Hazard Class: 3; Packing Group: II; Proper Shipping Name: FLAMMABLE LIQUIDS, TOXIC, N.O.S.
TSCA : TSCA
Recommended Storage : 2° to 8°C