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TRA-1-60 (podocalyxin) Mouse anti-Human, Biotin, Clone: TRA-1-60, eBioscience™

Mouse Monoclonal Antibody

$114.55 - $201.55

Specifications

Antigen TRA-1-60 (podocalyxin)
Clone TRA-1-60
Host Species Mouse
Species Reactivity Human
Applications Flow Cytometry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5012226

 
affymetrix
13-8863-80
25μg Each for $114.55

5012227

 
affymetrix
13886382
100μg Each for $201.55
Description & Specifications

Specifications

Antigen TRA-1-60 (podocalyxin)
Clone TRA-1-60
Host Species Mouse
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate Biotin
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The TRA-1-60 antibody recognizes a protein expressed on undifferentiated human embryonic stem cells (ES), embyronal carcinoma cells (EC), and embryonic germ cells (EG). Like other stem cell specific markers, the epitope recognized by the TRA-1-60 antibody is lost upon cell differentiation. Contrary to early reports that the TRA-1-60 epitope can be destroyed by neuraminidase digestion, new strudies have shown that TRA-1-60 recognizes a neurominidase resistent antigen. The TRA-1-60 antibody is known to specifically recognize a carbohydrate epitope on a keratan sulfated glycoprotein recently identified as podocalyxin, a member of the CD34-related family of sialomucins. Podocalyxin is a transmembrane glycoprotein originally identified on epithelial glomerular cells known as podocytes, and the protein has also been implicated in the development of aggressiveness in a variety of cancers, including breast and prostate cancer.