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TOX Rat anti-Mouse, PE, Clone: TXRX10, eBioscience™

Rat Monoclonal Antibody

$158.05 - $390.05

Specifications

Antigen TOX
Clone TXRX10
Host Species Rat
Gene Alias Thymocyte selection-associated HMG box protein
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50245515

 
affymetrix
12650280
25μg Each for $158.05

50245516

 
affymetrix
12650282
100μg Each for $390.05
Description & Specifications

Specifications

Antigen TOX
Clone TXRX10
Host Species Rat
Gene Alias Thymocyte selection-associated HMG box protein
Species Reactivity Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This TXRX10 monoclonal antibody reacts with human and mouse TOX, which is also known as Thymocyte selection-associated HMG box protein. This DNA-binding nuclear factor is expressed in thymocytes, T lymphocytes, NK cells, and lymphoid tissue-inducer (LTi) cells. TOX expression in thymocytes is upregulated during beta-selection and positive selection. Studies using Tox knockout mice have demonstrated a critical role for TOX in CD4+ T cell development as a regulator of the CD4loCD8lo to CD4+CD8lo transition. Moreover, TOX has been shown to be involved in the development of NK and LTi cells. While its regulation remains unclear, TOX expression has been shown to be induced by calcineurin-mediated TCR signaling in thymocytes during positive selection.