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TOX Rat anti-Mouse, eFluor 660, Clone: TXRX10, eBioscience™

Rat Monoclonal Antibody

$196.68 - $500.28

Specifications

Antigen TOX
Clone TXRX10
Host Species Rat
Gene Alias Thymocyte selection-associated HMG box protein
Applications Flow Cytometry (Intracellular Staining)
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124422 Life Technologies
LS50650280
25μg Each for $196.68
501124423 Life Technologies
LS50650282
100μg Each for $500.28
Specifications

Description

This TXRX10 monoclonal antibody reacts with human and mouse TOX, which is also known as Thymocyte selection-associated HMG box protein. This DNA-binding nuclear factor is expressed in thymocytes, T lymphocytes, NK cells, and lymphoid tissue-inducer (LTi) cells. TOX expression in thymocytes is upregulated during beta-selection and positive selection. Studies using Tox knockout mice have demonstrated a critical role for TOX in CD4+ T cell development as a regulator of the CD4loCD8lo to CD4+CD8lo transition. Moreover, TOX has been shown to be involved in the development of NK and LTi cells. While its regulation remains unclear, TOX expression has been shown to be induced by calcineurin-mediated TCR signaling in thymocytes during positive selection.
Description & Specifications

Specifications

TOX
Rat
Flow Cytometry (Intracellular Staining)
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL
TXRX10
Thymocyte selection-associated HMG box protein
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer