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TOX Rat anti-Mouse, Clone: TXRX10, eBioscience™

Rat Monoclonal Antibody

$117.48 - $236.28

Specifications

Antigen TOX
Clone TXRX10
Host Species Rat
Gene Alias Thymocyte selection-associated HMG box protein
Applications Immunoprecipitation,Western Blot
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013483 Life Technologies
LS14650280
25μg Each for $117.48
5013484 Life Technologies
LS14650282
100μg Each for $236.28
Specifications

Description

This TXRX10 monoclonal antibody reacts with human and mouse TOX, which is also known as Thymocyte selection-associated HMG box protein. This DNA-binding nuclear factor is expressed in thymocytes, T lymphocytes, NK cells, and lymphoid tissue-inducer (LTi) cells. TOX expression in thymocytes is upregulated during β-selection and positive selection. Studies using Tox knockout mice have demonstrated a critical role for TOX in CD4+ T cell development as a regulator of the CD4loCD8lo to CD4+CD8lo transition. Moreover, TOX has been shown to be involved in the development of NK and LTi cells. While its regulation remains unclear, TOX expression has been shown to be induced by calcineurin-mediated TCR signaling in thymocytes during positive selection.
Description & Specifications

Specifications

TOX
Rat
Immunoprecipitation,Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
TXRX10
Thymocyte selection-associated HMG box protein
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer